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TSTO Patents


CN101336640
Tetrasilver tetroxide bactericide, preparation method and use thereof


Inventor(s):     KAIMING JIANG, et al.

The present invention discloses a tetrasilver tetroxide fungicide, a preparing method and an application thereof. The tetrasilver tetroxide fungicide comprises the following components by weight part: weak alkaline solution 800-1200 parts, tetrasilver tetroxide 0.1-0.5 parts, and polyvinyl alcohol 8-20 parts. The preparing method of the tetrasilver tetroxide fungicide comprises the following steps: using the weak alkaline solution with pH value of 7.0-7.5 as dissolvent, fetching 800-1200 parts of weak alkaline solution, and adding 0.1-0.5 parts of tetrasilver tetroxide, sufficiently diluting; and uniformly mixing 8-20 parts of polyvinyl alcohol with the obtained solution in which the polyvinyl alcohol is used as carrier, and then the tetrasilver tetroxide fungicide is prepared. The invention also discloses the application of the tetrasilver tetroxide fungicide as a disinfection additive. The preparing method of the tetrasilver tetroxide fungicide according to the invention is simple and is suitable for large-scale production.

DESCRIPTION
[0001]

TECHNICAL FIELD
[0002]

The present invention relates to a tetroxide four silver bactericide, preparation method and application.
[0003]

Background technique
[0004]

Current research and application of fungicides mainly in the chemical control of diseases caused by fungi, and chemical research for the prevention and treatment of diseases caused by bacteria and viruses develop was not enough.

Bactericidal effect of silver had been discovered in recent years in the crack sterilization principle of silver, but also increasingly want to sterilization principle applied to products in the silver go, but not the silver as prevent bacteria, viruses, fungicides on the market and applied to product examples appear.

On the "Chinese Journal of New Drugs and Clinical" reported the July 2005 issue of "Advances in medical tetroxide four silver", he pointed out tetroxide four silver is expected to become a new type of anti-microbial agents and used in the treatment of AIDS, cancer and other diseases ???
[0005]

SUMMARY OF THE INVENTION
[0006]

OBJECTS OF THE INVENTION:

The purpose of the present invention is to provide tetroxide four silver oxide prepared by a four-four silver bactericide, preparation method and sterilization as additives.
[0007]

Technical Solution: A tetroxide four silver bactericide, which comprises the following components by weight: weak alkaline solution 800 to 1200 parts, four four silver oxide 0.1 to 0.5 parts, from 8 to 20 parts of polyvinyl alcohol.
[0008]

Four silver tetroxide bactericide comprises the following components by weight: weak alkaline solution of 1000 parts, 0.2 parts tetroxide four silver, 10 to 15 parts of polyvinyl alcohol.
[0009]

Preparation tetroxide four silver bactericide, which comprises the steps of:
[0010]

(1) PH value of the weak alkaline solution to 7.0 to 7.5 as the solvent, taking a weak alkaline solution 800 to 1200 parts, is added 0.1 to 0.5 parts tetroxide four silver sufficiently diluted;
[0011]

(2) 8 to 20 parts of polyvinyl alcohol as a carrier, a uniform mixed solution of polyvinyl alcohol in step (1) was that prepared tetroxide four silver bactericide.
[0012]

Step (1) in weakly alkaline solution of ammonia, sodium hydroxide or potassium hydroxide.
[0013]

Tetroxide four silver bactericide as bactericidal additives.
[0014]

Tetroxide four silver fungicide application as a sterilizing antimicrobial additive in plastics.
[0015]

Tetroxide four silver as bactericidal bactericide additive used in antibacterial fiber Products.
[0016]

Tetroxide four silver as bactericidal bactericide additive in antibacterial fabric applications.
[0017]

Tetroxide four silver bactericide additive used in the plant as a bactericidal against a variety of pathogenic microorganisms cause disease in.
[0018]

Tetroxide four silver bactericidal additive fungicide application as antimicrobial coatings.
[0019]

According to the mechanism of two fungicides:  interfere with the bacteria through the process of respiration, inhibit energy production to sterilization; bacterial life interfering substances such as protein biosynthesis, nucleic acids, alcohols, etc. to sterilization.

Bactericide tetroxide four silver produced as a fungicide belongs to the second type of mechanism.

Analysis tetroxide four silver (Ag4O4) mechanism of action, antimicrobial sequence silver ions are: Ag3 +> Ag2 +> Ag1 +, and tetroxide four silver (Ag4O4) is a unique conformation "multivalent silver" oxides, which with the protein surface exposed group and 2S group 2N redox reaction, thereby producing the protein causes a conformational change in the electrical killing effect and chelation.
Its mechanism of action is different from the general anti-microbial agents, the mode of action are unlikely to cause pathogen resistance or mutation, no toxicity to normal tissues, has anti-microbial and anti-disease cells.
[0020]

Beneficial effects: tetroxide four silver with disturbance, prevents bacteria, especially bacteria and viruses living matter biosynthesis role will tetroxide four silver in the form of sterilization bactericide additives in the production of antibacterial plastic products, antibacterial fiber products, anti-bacterial fabric , against a variety of plant diseases caused by pathogenic microorganisms, medical equipment and reagent additive, antibacterial paint and antibacterial sanitary and other widely used in these areas, with good inhibition of bacterial, viral effect, simple preparation method of the present invention, suitable for large scale industrial production, the application of the method is simple and practical.
[0021]

DETAILED DESCRIPTION
[0022]

Below in conjunction with the specific embodiments of the present invention will be described in further detail.
[0023]

Preparation tetroxide four silver bactericide: Example 1.
[0024]

(1) to PH value of ammonia (NH3) 7.0 solution of 1 kg of the solvent, 200 mg of the fully diluted tetroxide four silver;
[0025]

(2) to 0.01 kg of polyvinyl alcohol as a carrier, and the step (1) was uniformly mixed solution, i.e., to obtain 1 kg tetroxide four silver bactericide.
[0026]

Example 2: tetroxide four silver fungicide application as a sterilizing antimicrobial additive in plastics.
[0027]

Containing the resulting tetroxide four silver bactericide agents in Example 1 is sprayed onto the air filter, naturally obtained after curing and drying antibacterial effect of air filter implementation.
Tetroxide four silver bactericide may also be in the form of a plastic coupling agent added, is about dissolved tetroxide four silver fungicide solution sprayed onto the plastic particles, and then drying can be used.
[0028]

Upon examination, sprayed air filter tetroxide four silver bactericide in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria are mixed kind of survival 0 This shows tetroxide four silver bactericide kills bacteria and mold have effect.
[0029]

Example 3: tetroxide four silver fungicide application as a sterilizing antimicrobial additive in plastics.
[0030]

Air conditioning has been formed on the housing directly in Example 1 was tetroxide four silver bactericide or a mist coating manner tetroxide four silver bactericide in combination with air-conditioned housing.
Since the outer surface of the air conditioning is very smooth, can be corona treatment, that is, under high voltage electric field, the electron flow on the air conditioner shell surface strong impact that can make the shell surface fluff becomes rough, increase the surface area, when the fungicide with When contact with the surface, can produce good wetting, it will penetrate into the recessed groove is galling to go, by the anchor role, firmly bonded in a plastic housing.

Using this principle, the corona treatment after applying tetroxide four silver germicide mist or coating, dried at a temperature of 60 ~ 80 ? dried for 8 - 12 minutes, so that tetroxide four silver bactericide fixed by complexation plastic shell surface.
[0031]

Upon examination, it sprayed tetroxide four silver bactericide, air-conditioned enclosure Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria are mixed kind of survival 0 This shows tetroxide four silver bactericide kills bacteria and mold have effect.
[0032]

Four silver bactericide tetroxide preparation: Example 4.
[0033]

(1) to PH value of 7.2 0.5 kg of sodium hydroxide solution as solvent, was added 100 mg of fully diluted tetroxide four silver;
[0034]

(2) to 0.006 kg of polyvinyl alcohol as a carrier, and the step (1) was uniformly mixed solution, i.e., to obtain 0.5 kg of tetroxide four silver bactericide.
[0035]

Example 5: tetroxide four silver bactericidal additive fungicide application as antimicrobial fiber products.
[0036]

The drawing class PP fiber products and 60 ~ 85 ? solution of Example 4 was tetroxide four silver bactericide solution heated cross-linking the implementation, and then dried to obtain a bactericidal effect of antimicrobial fiber products.
[0037]

Upon examination, the coated tetroxide four silver bactericide drawing class PP fiber products in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria-like mix survival rates are zero, we can see tetroxide four silver bactericide kills bacteria and mold have effect.
[0038]

Example 6: tetroxide four silver as bactericidal bactericide additive used in antibacterial fiber Products.
[0039]

Example 4 was tetroxide four silver bactericide added hot melt adhesives, by a coating method has a bactericidal effect can be obtained child diapers.
[0040]

Upon examination, the coated tetroxide four silver bactericide children diapers in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria mixed kind of survival rate was 0, we can see tetroxide four silver bactericide kills bacteria and mold have effect.
[0041]

Example 7: tetroxide four silver as bactericidal bactericide additive used in antibacterial fiber Products.
[0042]

The tetroxide in Example 4 was added to the four silver bactericide hot melt adhesives, by coating method can be obtained sanitary napkins, sanitary pads has a bactericidal effect.
[0043]

Upon examination, the coated tetroxide four silver bactericide sanitary napkins, sanitary pads in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria-like mix survival rates are zero, we can see tetroxide four silver bactericide kills bacteria and mold have effect.
[0044]

Example 8: tetroxide four silver bactericidal additive fungicide application as antimicrobial fabric.
[0045]

The health care workers and patients clothing soaked in the solution obtained in Example 4 tetroxide four silver bactericide, the dehydration solution recovered by centrifugation, dry, drying to obtain health care workers has an antibacterial effect and patient clothing.
[0046]

Upon examination, the infiltration had tetroxide four silver bactericide medical staff and patients clothing Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria mixed kind of survival are 0, we can see tetroxide four silver bactericide kills bacteria and mold have effect.
[0047]

Example 9: tetroxide four silver bactericidal additive fungicide application as antimicrobial fabric.
[0048]

The bandage was dipped in a solution prepared in Example 4 tetroxide four silver bactericide, the dehydration solution recovered by centrifugation, dry, dry, prepared as wound paste with antibacterial effect.
[0049]

Upon examination, the infiltration had tetroxide four silver bactericide wound paste in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria are mixed kind of survival 0 This shows tetroxide four silver bactericide kills bacteria and mold have effect.
[0050]

Tetroxide four silver fungicide Preparation: 10 Example.
[0051]

(1) in a potassium hydroxide solution PH value of 7.5 to 2 kg solvent, was added 400 mg of fully diluted tetroxide four silver;
[0052]

(2) to 0.03 kg of polyvinyl alcohol as a carrier, and the step (1) was uniformly mixed solution, i.e., 2 kg of the obtained tetroxide four silver bactericide.
[0053]

Example 11: tetroxide four silver fungicide applications against a variety of plant diseases caused by pathogenic microorganisms in.
[0054]

When watering the wheat can be implemented 10 prepared in Example tetroxide four silver bactericide concentration is diluted to 10 ~ 30ppb by spraying or sprinkling method can effectively prevent the wheat disease caused due to a variety of pathogenic microorganisms.
[0055]

Wheat Upon examination, poured over tetroxide four silver fungicide containing water after E. coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria-like mix of survival are 0, we can see tetroxide four silver bactericide kills bacteria and mold have the role to effectively suppress diseases caused by pathogenic microorganisms.
[0056]

Example 12: tetroxide four silver fungicide applications against a variety of plant diseases caused by pathogenic microorganisms in.
[0057]

Tetroxide four silver bactericide prepared in Example 10 was to be implemented in 10 ~ 30ppb dilution, spraying or sprinkling with a method to sprinkle on apple trees, apple trees can effectively prevent diseases caused due to a variety of pathogenic microorganisms.
[0058]

Upon examination, it poured over the tree tetroxide four silver fungicide containing water after E. coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria mixed kind of survival rate was 0, we can see tetroxide four silver bactericide kills bacteria and mold have the role to effectively suppress diseases caused by pathogenic microorganisms.
[0059]

Example 13: tetroxide four silver fungicide applications against a variety of plant diseases caused by pathogenic microorganisms in.
[0060]

The tetroxide in Example 10 was four silver fungicide to 10 ~ 30ppb dilution, spraying or sprinkling with a method to sprinkle on the lawn, which can effectively prevent lawn diseases caused due to a variety of pathogenic microorganisms.
[0061]

Upon examination, pouring water over the lawn after tetroxide four silver-containing fungicides, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria mixed kind of survival are 0, we can see tetroxide four silver bactericide kills bacteria and mold have the role to effectively suppress diseases caused by pathogenic microorganisms.
[0062]

Example 14: tetroxide four silver bactericidal additive fungicide application as antimicrobial coatings.
[0063]

The tetroxide in Example 10 was four silver fungicide concentration 10 ~ 50ppm added to paints, coatings, paints or paint spraying these handrails, computers, telephones, toys and wooden floors often use bacteria more on items, so that the sprayed paints, coating materials having antibacterial effect.
[0064]

Upon examination, it sprayed tetroxide four silver-containing fungicides Paints, paint handrails, computers, telephones, toys and wooden floors, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, aerogenes, orange grass shoots crisp bacillus, bacteria mixed kind of survival are zero, we can see tetroxide four silver bactericide kills bacteria and mold have effect.