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Shuo CHEN / Abshar HASAN :
Dental Enamel Regrowth
https://www.linkedin.com/posts/jbecher_biomimetic-supramolecular-protein-matrix-activity-7395213882195218432-0LMo
New gel repairs and rebuilds tooth enamel with natural growth
The protein-based gel uses the human body’s natural growth processes to form a durable coating and fill in small cavities in teeth. After being coated on a target tooth’s surface, it extracts calcium and phosphate ions from saliva to encourage new growth of minerals. These minerals then merge with the existing tooth, effectively allowing it to regrow lost enamel. Lab experiments showed that a thin, protective layer formed within just weeks of applying the gel to extracted human molar teeth.
https://www.nature.com/articles/s41467-025-64982-y
Nature Communications volume 16, Article number: 9434 (2025)
Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel
Abshar Hasan, et al
Abstract -- Tooth enamel is characterised by an intricate hierarchical organization of apatite nanocrystals that bestows high stiffness, hardness, and fracture toughness. However, enamel does not possess the ability to regenerate, and achieving the artificial restoration of its microstructure and mechanical properties in clinical settings has proven challenging. To tackle this issue, we engineer a tuneable and resilient supramolecular matrix based on elastin-like recombinamers (ELRs) that imitates the structure and function of the enamel-developing matrix. When applied as a coating on the surface of teeth exhibiting different levels of erosion, the matrix is stable and can trigger epitaxial growth of apatite nanocrystals, recreating the microarchitecture of the different anatomical regions of enamel and restoring the mechanical properties. The study demonstrates the translational potential of our mineralising technology for treating loss of enamel in clinical settings such as the treatment of enamel erosion and dental hypersensitivity.
https://www.pnnl.gov/publications/how-proteins-form-tooth-enamel
How Proteins Form Tooth Enamel
Protein ribbons are highly active scaffolds for apatite formation...New research published in the Proceedings of the National Academy of Sciences USA from an international collaboration between Pacific Northwest National Laboratory (PNNL) and University of Washington scientists, studied how recently identified amelogenin ribbons interacted with an amorphous mineral precursor of apatite....
https://www.researchgate.net/profile/Shuo-Chen-6
Shuo Chen -- The University of Texas Health Science Center at San Antonio
SUBSTRATES COMPRISING ELASTIN-LIKE POLYPEPTIDES AND CALCIUM IONS
US2025145663 // US2024301032
The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.
Method and application for inducing fluoro-calcium silicate biomimetic mineralization based on amelogenin
CN109288685
The invention discloses a method and an application for inducing fluoro-calcium silicate biomimetic mineralization based on amelogenin, and belongs to the field of biomedical materials. Fluoro-calciumsilicate in mineralizing solution is induced by the amelogenin to form a biomimetic mineralization material. By starting with the self-assembly capacity of the amelogenin, the fluoro-calcium silicateserves as an inorganic bioactive material in the biomimetic mineralizing solution to build nano-sized and micron-sized biomimetic hard tissue mineralization layers. The formed mineralization layers are superior to mineralization layers formed by pure inorganic ceramic bioactive materials, and grain crystals are orderly arranged and grow in an orientated manner along a sizing shaft to form a nano-apatite grain crystal structure similar to bones and teeth.
AMELOGENIN-CHITOSAN HYDROGEL FOR DENTIN HYPERSENSITIVITY
US2018236130
A method to regrow a protective layer over exposed/demineralized dentin that includes a step of identifying a subject having exposed/demineralized dentin. The demineralized dentin is contacted with a remineralization composition that includes an amelogenin and derived peptides, a chitosan, water, and a sufficient amount of a pH adjusting component such that the composition has a pH greater than about 6.0 such that dentinal tubules are occluded with apatite crystals and enamel is regrown on the dentinal tubules.