rexresearch.com
rexresearch.com
Fredric SCHIFFER / Robert BUCK
Therapeutic Glasses
http://www.impactlab.net/2006/05/22/sunglasses-help-you-handle-stress/
May 22nd, 2006
Sunglasses that relieve Stress?
The love of your life stood you up. You were passed over for a promotion. Your sports car was towed from a no-parking zone. A professor flunked you. You are angry. The adrenaline is pumping. Your teeth are grinding. You want revenge. You are out of control. Hold on. Science might have found a way to help. The secret could be in a new sunglasses design that is said to bring calm and rationality within minutes of wearing them.
Marketed as NeuView ( www.neuviewglasses.com ), the glasses direct light at an angle to the optic nerve. The result is said to activate the more rational left side of the brain to balance the emotional right brain that is inflamed during stressful moments.
They’re called lateral glasses, and the idea was researched and developed for psychotherapy by Fredric Schiffer of the Harvard Medical School. Veteran psychotherapist Robert Buck, in Hastings-on-Hudson, N.Y., modified the glasses and obtained a patent. Buck compares the process to turning on the light in a dark room so that you can see the entire room. When a man whose car had been towed came to his office several days after the incident threatening to flatten tires where he was parked, Buck gave him the glasses. Within seconds, he was able to say, “I don’t have to do that.”
Kansas City boxer Katie Dallam, who was severely injured in a fight, has worn them before a television interview to keep her calm, Buck said. The glasses have been used by experienced golfers, before putting, to activate the right side of the brain as a balance to the over-active strategizing left side.
The glasses are $72, including shipping charges, at the Web site.
http://www.neuviewglasses.com/
NEUVIEW GLASSES
Now NeuView Sunglasses offer you a non-pharmaceutical way to lower your stress and anxiety. These patented "lateralized glasses" are based on research conducted by a leading neuroresearcher at Harvard Medical School and endorsed by mental health professionals in the U.S. and abroad.
NeuView Sunglasses are a specially designed pair of sunglasses with wraparound lenses that have side sections that can be raised to let in more light on one side or the other.
With NeuView Sunglasses you can easily and safely create the healthful balance between the right and left sides of your brain. And, by doing so, bring all you resources to bear to deal with the stress in your life.
NeuView Glasses help you to:
Sort out the real from the perceived threats of everyday life
Manage stress in any environment: at home, at work, or at play
Improve athletic performance by focusing and balancing your mental and physical energy
WHAT ARE NEUVIEW GLASSES?
Glasses unlike any you have ever worn. NeuView Glasses are lateralized glasses. What does that mean? It simply means that they enable the user to access unfiltered light to either his extreme right or left visual field. This is accomplished by raising the right or left windows. This simple act initiates a profound and positive neurological event: namely, the stimulation and increased activation of the cerebral hemisphere opposite the light source.
WHAT DO THEY DO?
NeuView Glasses enhance our ability to be "whole brain" thinkers. They provide us with a view as to how we experience our world, cognitively, emotionally, and even somatically, from both our right- brain and our left-brain. Often this view will be experienced as dramatically different from one side to the other. One individual who experienced himself as "a samurai warrior with my sword at the ready" on one side, was amazed and comforted by experiencing himself as "a shepherd tending my flock" on the other side. Now, with Neuview Glasses, the "right-brain person" has the opportunity to experience his less dominant left brain, and the "left-brain person" is introduced to his lesser known right brain. When this occurs we are presented with an important opportunity — the integration of knowledge and experience heretofore unavailable in our singular view of ourselves.
However, it is our ability to shift back and forth between the two hemispheres that is, crucial to our sense of well-being, as well as to our success in the workplace. With NeuView Glasses the user can easily make these shifts that lead to an integrated view. NeuView Glasses enhance our sense of well-being.
While using the glasses many people have the positive experience of "being more in touch with their feelings" for others it can be the experience of having overwhelming feelings of anxiety, panic, or depression subside when they access comforting information from their left brain. For the person with ADD it can be experiencing order where heretofore there was only chaos. In one such case, an extremely anxious test taker who studied long and hard for the exam and yet couldn't see how he would pass, knew instantly that he'd be fine and said, "I know the stuff" as he accessed that awareness held within his left brain. He did pass, he was right, he knew "the stuff."
What do NeuView Glasses do?
They give us a new view — and the opportunity for a truer, healthier, more integrated view of ourselves and of the world.
http://vimeo.com/52108471
US6145983
Method for using therapeutic glasses for stimulating a change in the psychological state of a subject
Therapeutic glasses for changing the psychological state of a user and a method for using the glasses are disclosed. The therapeutic glasses include at least one lens of a size sufficient to cover an eye of the user, wherein at least one lens restricts vision to a lateral visual field. The method includes wearing the glasses for a sufficient period of time, thereby stimulating the user to achieve a change in the psychological state of the user.
BACKGROUND OF THE INVENTION
It has been known since antiquity that the brain is composed of two hemispheres, and people have been attempting for centuries to exploit this fact in explanations of psychological function. By the middle of the 19th century, neurologists had begun to understand that the left hemisphere was dominant for language. In this century, scientists have found the right hemisphere to be dominant for other abilities, such as the understanding and expression of emotion. This partial independence of hemispheres was confirmed in split brain experiments in animals and later in humans showing that hemispheric specialization and partial hemispheric independence could exist together. Research has found that in normal persons the right brain has intelligence and autonomous mental functions separate from those of the left brain.
The right brain and left brain are capable of having their own mentation and actions. Observations have indicated that the cognitive faculties of the right brain in split brain and left-hemispherectomy patients can be fully developed. An isolated right hemisphere has the capacity for autonomous perception, memory, thought, emotion and volition. The right brain, in split-brain patients, can also induce or affect behavior without a correct conscious, left-sided understanding of the reason behind it. In normal individuals, the right hemisphere can have intact mental faculties, separate from and often beyond the awareness of the patient's left-sided mind.
Therefore, a need exists for an apparatus and method that can stimulate a subject by changing the side of the brain which predominates to achieve a change in the psychological state of the subject.
SUMMARY OF THE INVENTION
The present invention is directed to therapeutic glasses for changing the psychological state of a user and is also directed to a method of using the therapeutic glasses.
The therapeutic glasses include at least one lens of a size sufficient to cover an eye of the user, wherein at least one lens sufficiently restricts vision to a lateral visual field to achieve a change in the psychological state of the subject and wherein the lateral visual field can be selectively changed by the user. The lens can be selectively adjusted by the user to change the restriction of vision to a different lateral visual field.
The method includes providing to a user therapeutic glasses having at least one lens of a size sufficient to cover an eye of the subject, wherein at least one lens restricts vision to a lateral field. The therapeutic glasses are worn for a sufficient period of time, thereby stimulating the user to achieve a change in the psychological state of the user.
The present invention has many advantages. The glasses are useful for treating people having psychological symptoms, such as anxiety, depression, post-traumatic stress disorder, compulsions, eating disorders, addictions, attention deficit disorders and psychoses. Further, the invention is useful for helping to relieve stress and to enhance a person state of well-being.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of one embodiment of the present invention.
FIG. 2 is a perspective view of a second embodiment of the present invention.
FIG. 3 is a perspective view of a third embodiment of the present invention.
FIG. 4 is a perspective view of a fourth embodiment of the present invention.
DETAILED DESCRIPTION OF THE INVENTION
The features and details of the method and apparatus of the invention will now be more particularly described with reference to the accompanying drawings and pointed out in the claims. The same numeral present in different figures represents the same item. It will be understood that the particular embodiments of the invention are shown by way of illustration and not as limitations of the invention. The principal features of this invention can be employed in various embodiments without departing from the scope of the invention. All percentages and parts are by weight unless otherwise indicated.
This invention relates to therapeutic glasses for changing the psychological state of a user. As shown in FIG. 1, one embodiment of the invention is therapeutic glasses 10 formed from modified safety glasses of a transparent composition, such as polycarbonate or polystyrene, and having first lens 12 and second lens 14. Bows 15 extend sufficiently to pass over the ears of the user. Therapeutic glasses 10 are suitable for covering at least one eye of the wearer. Therapeutic glasses 10 are covered on either the inside or outside surface of first lens 12 and second lens 14 with an essentially opaque substance, such as an adhesive tape, paint or other similar coating that can block the view of the wearer. Alternatively, first lens 12 and second lens 14 can be impregnated with the opaque substance. Typically, first lens 12 (right lens) is fully coated and portion 16 covers about half of second lens 14 (left lens) proximate to bridge 18 of therapeutic glasses 10. Therapeutic glasses 10 are configured to restrict viewing to area 20 of the left half of second lens 14. Covered portion 16 of second lens 14 can have a covered area in the range of between about 50 and 75 percent. In a preferred embodiment, second lens 14 is covered on about sixty percent of the area. Such therapeutic glasses can be worn by a user for a sufficient period of time, thereby stimulating the user to achieve a change in the psychological state of the user.
As shown in FIG. 2, second therapeutic glasses 30 are essentially the same as therapeutic glasses 10 shown in FIG. 1. In this embodiment, first lens 32 (right lens) has partially covered area 34 proximate to bridge 36 and transparent area 38 is distal from bridge 36 for limiting vision to the right lateral visual field of the right eye. Bows 35 extend sufficiently to pass over the ears of the user. Second lens 40 (left lens) is sufficiently opaque to block vision.
As shown in FIG. 3, another embodiment of the invention includes third therapeutic glasses 50 having frame 52 typically used in eyeglasses and sunglasses. Frame 52 can be formed of a suitable material, such as wire or plastic.
Therapeutic glasses 50 has first lens 54 and second lens 56. First lens 54 can be opaque on first side 58 proximate to bridge 60. Bows 55 extend sufficiently to pass over the ears of the user. Second side 62 can be essentially transparent. The tinting is substantially uniform along the vertical axis of first lens 54 and second lens 56. First lens 54 and second lens 56 can be tinted with various colors, such as blue, red or green. The color blue has been found to be particularly favorable by users. Alternatively, first lens 54 and second lens 56 are essentially opaque or dark on the right side of each and progressively less tinted towards the left side of the lenses where they can be essentially clear. In a preferred embodiment, the outer surfaces of the lenses are coated with a reflective material, such as gold, silver or aluminum, to provide a uniform appearance to a viewer, thereby giving the impression that the wearer is wearing regular sunglasses.
First lens 54 and second lens 56 can be tinted with a photochromic material that allows the tinting to change as a result of lighting conditions. Alternatively, portions of the lenses can be tinted with an electrochromic material, which can be powered by a control unit and battery, to allow the user to change the degree of tinting in the lenses as desired and select the lateral visual field to be restricted. An example of a suitable tinting material and control unit is shown in U.S. Pat. No. 5,264,877, issued to Hussey, the teachings of which are incorporated herein by reference. Therapeutic glasses 50 can have the lenses mounted to frame 52 to allow them to be flipped up in direction 64 in a manner similar to sunglasses worn by baseball players.
First lens 54 and second lens 56 in frame 52 can be mounted in a manner to allow the lenses to be rotated in direction 66 in which the plane the lenses lie. For example, the user may desire to rotate first lens 54 and second lens 56 in order to change the visual field restriction from the left side to the right side, thereby stimulating a different change in the psychological state of a user.
As shown in FIG. 4, therapeutic glasses 80 has first lens 82 and second lens 84 in frame 86 which has bridge 88 between the lenses approximately midway between top portion 90 and bottom portion 92 of the glasses. First lens 82 and second lens 84 can have a gradient tint similar to the lenses disclosed in FIG. 3. Bridge 88 is configured to allow therapeutic glasses 80 to be flipped around and worn upside down in order to block the opposite lateral field. For example, therapeutic glasses 80 can have the right side of first lens 82 and second lens 84 sufficiently opaque to restrict vision to the right lateral visual field. Therapeutic glasses 80 can then be flipped around and worn with the left lateral visual field blocked. Bows 85 are sufficiently straight to pass over the ears of the user to allow the user to wear therapeutic glasses 80 in either direction. Bows 85 can be slightly curved in toward the head of the user to help secure the glasses. Depending on the hemisphere the wearer would like to stimulate, therapeutic glasses 80 are worn with the left visual field blocked or the right visual field blocked.
Another embodiment of the invention includes a contact lens having a tint gradient along the horizontal axis from left to right or right to left while having a substantially uniform tint gradient along the vertical axis of the contact lens. The tint gradient along the horizontal axis is preferably linear. The lens sufficiently restricts vision to a lateral visual field to achieve a change in the psychological state of the wearer.
The therapeutic glasses have been found to be beneficial to a patient undergoing psychotherapy. The therapeutic glasses can be worn during psychotherapy sessions with a psychotherapist. In combination with psychotherapy sessions or by themselves, the therapeutic glasses can help reduce symptoms of anxiety, depression or a compulsive disorder, such as an eating disorder, including anorexia nervosa and bulimia. Other compulsive disorders including alcohol abuse and gambling may be helped. Other problems that can be helped include dyslexia, stress-induced heart disease and post-traumatic stress disorder. The therapeutic glasses can be used in counseling and for use in amplifying, diagnosing or describing a psychological problem. The therapeutic glasses are useful for circumstances where one hemisphere of the brain is visually stimulated over the other hemisphere by differentially stimulating the retinas. Such a stimulation can result in electroencephalographic (EEG) activity, indicating a shift in hemispheric dominance.
In psychotherapy a patient can alternate between lateral visual fields and induce both an increase and a decrease in the person's symptoms to show him that his fears reside only in a part of his mind. The embodiments in FIGS. 3 and 4 are designed to facilitate easy switching between the left and right lateral fields. In the embodiment shown in FIG. 3, both lenses can be rotated 180 degrees to change the lateral visual field which is stimulated. In the embodiment shown in FIG. 4, the entire frame can be rotated 180 degrees to change the lateral visual field which is stimulated. With the embodiments shown in FIGS. 1 and 2, the subject can switch between embodiments to alter the lateral visual field which is stimulated. The method allows some patients who have had only a negative view of the world to see the world from a new more optimistic, more mature perspective.
The user does not need to undergo psychotherapy or the like to benefit from using the therapeutic glasses. Many people, who are considered normal and wear the therapeutic glasses, can perceive a reduction in stress and increase in well being. Depending upon the individual and the change in psychological state desired, the user can selectively change the restriction of the visual field to the field that provides the desired result.
The therapeutic glasses are worn at various times, such as during psychotherapy counseling sessions and times of anxiety or at any time the wearer wants to decrease his stress. The therapeutic glasses are worn for a sufficient period of time that can be in the range of between a few minutes and many hours to stimulate the user to achieve a change in the psychological state of the user. For example, the therapeutic glasses can be worn by a passenger on an airplane to help reduce the anxiety of flying. In another embodiment, the therapeutic glasses are worn at home or in the office during a period of anxiety. The therapeutic glasses with translucent material can be worn while walking. However, because the therapeutic glasses with opaque restrict the vision of the user to one visual field while wearing, it is recommended that the glasses be worn while sitting or lying down. Walking with them should only be attempted after much experience while wearing. It is not recommended operating an automobile or heavy machinery while wearing the therapeutic glasses with opaque material.
Although not wanting to be limited to a theory why the therapeutic glasses are effective in treating numerous problems and disorders, it is believed that certain changes in the psychological state of a person can be changed by stimulating one hemisphere of the brain separately from the other hemisphere. Whether it is the left or right hemisphere which dominates can often markedly affect a person's personality and some of the psychological systems he might have. By restricting vision to a portion of the retina of an eye that is connected to a particular hemisphere of the brain, that hemisphere can be stimulated preferentially. The eyes are connected to the brain so that vision to the left side of a person goes first to the opposite (right) hemisphere and vision to the right side of a person goes first to the left hemisphere.
It is believed that humans can have two autonomous minds, one associated with the left brain and one with the right brain and that there is a human relationship between human left and right minds, and the issues which apply to any relationship apply to the one within us. For example, in some people the left minds "dominate" and "suppress" their right minds. In others, the right mind can dominate. Symptoms can be produced if a trouble side dominates the personality. For example, some of these right dominant people are called "neurotic", because they express emotions or engage in behaviors that are difficult to understand and often seem irrational. Of course, some peoples' minds live in harmony with mutual respect and cooperation.
To test the efficacy of the therapeutic glasses, seventy out-patient psychotherapy patients were asked to participate. All gave written, informed consent, and each participated without remuneration. The patients ranged in age from 18 to 73 with a mean of 43 (sd=10.8). There were 39 males. Eleven patients were left-handed and 59 were right-handed by the Edinburgh Handedness criteria. The primary, current DSM-IV diagnoses by structural clinical research interviews fell into six groups: 1) dysthymic disorder (N=20); 2) anxiety disorders (N=7); 3) major depression (N=21); 4) schizophrenia (N=2); 5) bipolar I disorder (N=2); and 6) post-traumatic stress disorder (PTSD) (N=18). Thirty-seven were taking psychotropic medications, most commonly serotonin reuptake inhibitors or benzodiazepins or both. Thirty-three had not taken medications for at least two weeks prior to the study.
Two pairs of therapeutic glasses, as shown in FIGS. 1 and 2, were constructed, each made by covering safety glasses with a white adhesive tape over one side and about sixty percent of the medial aspect of the other side. Each pair of therapeutic glasses was taped so that it permitted vision to only either the left visual field or the right visual field. Patients were free to move their eyes, head or body, but were encouraged to look out of the exposed area so that about half of their visual field on that side was obstructed.
Following objective questions about their level of anxiety in the different conditions, 42 patients were engaged, who found at least a one point difference on a five-point anxiety scale (none, mild, moderate, quite-a-bit or extreme) between lateral visual fields, in an unstructured interview while they wore the therapeutic glasses a second time, shortly after the first. On repeat trials, as part of a pilot study, seven additional patients responded to the therapeutic glasses and were also interviewed with the glasses on.
Of these 49 patients who experienced at least a one-point difference in anxiety between sides, the mean age was 42.9 (sd=9.8). There were 24 females and 39 right-handed patients. Twenty-seven were taking psychotropic medications.
Three of these responsive patients were tested in a follow-up session in which their EEG's were monitored during two baseline periods, as well as while they wore, in randomized order, the experimental therapeutic glasses and two comparison goggles. The comparison goggles were constructed so that either the left or right side was completely taped, and the other side was taped only over the bottom fourth of the lens. These comparison goggles allowed for monocular vision which a number of studies have demonstrated can activate the contralateral hemisphere. The bottom one fourth of the unoccluded side of the comparison goggles was taped to give them a more complex appearance in an attempt to disguise that they were being used as a control. At least ninety seconds of EEG tracings were recorded in each condition with electrodes placed in a standard 10/20 system. The electrodes were referenced to linked mastoids and all impedances were less than five ohms. After artifact removal, an asymmetry index (L-R/L+R) was calculated from the means of the frontal and temporal leads on the left (F1, F3, F7, T3, T5) and right (F2, F4, F8, T4, T6) sides for both the theta and the alpha power spectrums. The asymmetry indices for the two pairs of therapeutic glasses were compared as were those for the comparison goggles and the two baseline recordings.
By Pearson chi-square tests, there were no significant differences between the 49 responders and the 21 non-responders, who were not interviewed, on the basis of diagnosis, sex, medication or handedness, although handedness approached significance (chi-square=2.717, df=1,68) p=0.099 because 91% left handers were responders.
Forty of the 49 patients interviewed reported feeling more regressed and symptomatic on one side and more mature and less symptomatic on the other. These patients usually reported being surprised by their experience. Twenty-six patients later consistently used the therapeutic glasses in their ongoing psychotherapy, and all of these patients found their use in therapy sessions to be of value.
All three patients tested with EEG monitoring manifested changes in their laterality indices with the two pairs of therapeutic glasses in the expected direction. That is, for each, the asymmetry index (L-R/L+R) derived from the mean frontal and temporal leads for theta activity was greater with the left vision field therapeutic glasses than with the right vision field therapeutic glasses (mean difference=-0.023 .mu.v, sd=0.025). In these patients, the lateralized differences were greater with the therapeutic glasses than with the comparison goggles (mean difference=-0.0144, sd=0.039) or with the repeated baseline conditions (mean difference=0.0076, sd=0.030). For these three patients, none of these differences were statistically significant by the Wilcoxon Rank-Sum Test.
A test was conducted to determine whether lateral visual field stimulation could alter EEG activity and affect in a laboratory setting. A comparison was conducted of EEG and anxiety level changes induced by two pairs of experimental goggles, each taped over one lens entirely and over the middle 60% of the other side, and by two pairs of comparison goggles. The experimental goggles restricted vision to the left visual field (LVF) or right visual field (RVF); the comparison goggles, to the left or right eye. Eleven subjects, ten right-handed, seven male, included three patients with PTSD and eight asymptomatic college students. The theta and alpha EEG activity in the mean of frontal and temporal leads was compared. All leads were referred to linked mastoids. Ninety seconds of EEG's were recorded in each condition and after artifact removal. A laterality index (LI), which equals (L-R)/(L+R), for each pair of randomly presented goggles was calculated.
With the experimental goggles the mean laterality index for the eleven subjects was less with the RVF than the LVF. The RVF-LVF difference in LI was -0.109, sd=0.19, (Wilcoxon Signed-Rank=-26.00, p=0.019) for theta, and -0.033, sd=0.054 for alpha (Signed-Rank=-21.00, p=0.067). For the comparison goggles, the R-L difference in LI was -0.033, sd=0.08 for theta (Signed-Rank=-9, p=0.25) and 0.002, sd=0.078 for alpha (Signed-Rank=0.00, p=1). The absolute differences in anxiety levels (rated on a 5 point scale) between experimental goggles were significantly greater than those between comparison goggles by Wilcoxon Signed-Rank test, Signed-Rank=10.5, p=0.031. Thus, restricting vision to lateral visual fields appeared to activate the contralateral hemisphere and to change anxiety levels from those of the other lateral field.
Methods for Treating Psychiatric Disorders Using Light Energy
US8574279
Methods for treating psychiatric disorders using light energy are disclosed herein. A method for treating psychiatric disorders using light energy includes determining which hemisphere of the brain requires treatment using lateral visual field stimulation (LVFS) and applying light energy to the hemisphere of the brain to treat the psychiatric disorder other than depression. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders. In an embodiment, the methods may be used to treat a psychiatric disorder co-morbid with depression.
RELATED APPLICATIONS
[0001] This application is a continuation of copending U.S. Utility application Ser. No. 13/481,820, filed on May 26, 2012, which claims the benefit of U.S. Utility application Ser. No. 12/855,258, filed on Aug. 12, 2010, which claims the benefit of priority from U.S. Provisional Patent Application No. 61/233,318, filed on Aug. 12, 2009, the entireties of each which are hereby incorporated herein by reference.
FIELD
[0002] The embodiments disclosed herein relate to the treatment of psychiatric disorders, and more particularly to the treatment of psychiatric disorders using light energy.
BACKGROUND
[0003] The application of intense light, a non-ionizing phototherapy, has been reported in over a thousand scientific publications to have therapeutic efficacy for a wide range of disorders in humans without any observed harmful effects. Light has been demonstrated in cell culture to increase mitochondrial respiration, increase ATP synthesis, increase heat shock proteins, induce transforming growth factor ß-1, and increase nerve cell proliferation and migration. Light has been tested in animals to facilitating wound healing, promote the process of skeletal muscle regeneration, and reduce infarct size in ischemic heart muscle by 50 to 70% in an induced experimental model in rats and dogs. Light in the near infrared spectrum, which penetrates the scalp and skull, can significantly reduce damage from experimentally induced stroke in rats and rabbits, and to improve the memory performance of middle aged mice, and reduce damage from acute stroke in humans. A method of treating psychiatric disorders using light energy is needed.
SUMMARY
[0004] Methods for treating psychiatric disorders using light energy are disclosed herein.
[0005] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain requires treatment using lateral visual field stimulation (LVFS) and applying light energy to the hemisphere of the brain to treat the psychiatric disorder other than depression. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0006] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient, including measuring a left hemispheric emotional valence and a right hemispheric emotional valence for a left hemisphere of the brain and a right hemisphere of the brain using a lateral visual field stimulation test; determining which hemisphere of the brain needs treatment; and applying light energy to the hemisphere of the brain to treat the psychiatric disorder co-morbid with depression.
[0007] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient, including measuring a left hemispheric emotional valence for a left hemisphere of the brain and a right hemispheric emotional valence for a right hemisphere of the brain using a lateral visual field stimulation test; determining the hemisphere of the brain in need of treatment; and applying light energy to the hemisphere of the brain to treat the psychiatric disorder co-morbid with depression.
[0008] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain has a more positive psychology or valence, using lateral visual field stimulation (LVFS), and applying light energy to the hemisphere with the more positive valence. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0009] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain has a more negative psychology or valence, using lateral visual field stimulation (LVFS), and applying light energy to the hemisphere with the more negative valence to improve its functioning. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0010] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain has a more positive and negative psychology or valence, using lateral visual field stimulation (LVFS); applying light energy to the hemisphere with the more positive affect; and applying light energy to the hemisphere with the more negative effect. In an embodiment, if both hemispheres have about equal levels of positive or negative valence, both hemispheres may benefit from the light energy. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0011] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain has a more negative psychology or valence, using lateral visual field stimulation (LVFS); applying light energy to the hemisphere with the more negative affect; and increasing cerebral blood flow in the opposing hemisphere. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0012] According to aspects illustrated herein, there is provided method for treating a patient, including determining which portion of the brain of the patient requires treatment; and applying light energy to the portion to treat the patient. The light might be applied bilaterally over the left and the right dorsolateral pre-frontal corticies. In an embodiment, the treatment may be used to treat depression. In another embodiment, the treatment may be used to improve the well-being of the patient.
[0013] According to aspects illustrated herein, there is provided a method for treating a patient, including determining which portion of the brain needs treatment; and applying light energy to the portion of the brain to treat the patient. In an embodiment, the treatment may be used to treat depression. In an embodiment, the treatment may be used to cause an improvement in the well-being of the patient.
[0014] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient including applying light energy to a brain to treat the psychiatric disorder.
BRIEF DESCRIPTION OF THE DRAWINGS
[0015] The presently disclosed embodiments will be further explained with reference to the attached drawings, wherein like structures are referred to by like numerals throughout the several views. The drawings shown are not necessarily to scale, with emphasis instead generally being placed upon illustrating the principles of the presently disclosed embodiments.
[0016] FIG. 1 shows a front view of glasses used for lateral visual field stimulation.
[0017] FIGS. 2A-2B show images of the brain having different activity by functional magnetic resonance imaging (fMRI) in the left and right cerebral hemispheres after looking out of the left or the right lateral visual field. FIG. 2A shows brain activity after looking out of the left half of the left eye (the left lateral visual field). FIG. 2B shows brain activity after looking out of the right half of the right eye (the right lateral visual field).
[0018] FIG. 3 shows NIR light being applied to the left side of the head using Photobiomodulation (PBM). The patches above the patient's eyebrows are connected to a commercial device for measuring cerebral blood flow in the front of the brain on the left and the right sides.
[0019] FIG. 4 shows a close up of the NIR-PBM device of FIG. 3.
[0020] FIG. 5 shows a control unit of the NIR-PBM device of FIG. 3.
[0021] FIG. 6 shows that there was an increase in cerebral blood flow when the NIR light was on compared to when it was off.
[0022] FIG. 7 shows that after the NIR treatment, there was an increase in positive affect when the brain hemisphere with a positive emotional valence was treated (matched treatment and hemisphere), but a decrease in positive affect when the brain hemisphere with a negative emotional valence was treated (unmatched).
[0023] FIG. 8 shows that at 2-weeks post treatment, a decrease in anxiety (as measured by the Hamilton Anxiety Rating Scale) was related to the patient's baseline hemispheric emotional valence (HEV) and cerebral blood flow. Those patients with a left negative HEV and an increase in right frontal CBF had less anxiety, as did those patients with a right negative HEV and an increase in left frontal CBF.
[0024] While the above-identified drawings set forth presently disclosed embodiments, other embodiments are also contemplated, as noted in the discussion. This disclosure presents illustrative embodiments by way of representation and not limitation. Numerous other modifications and embodiments can be devised by those skilled in the art which fall within the scope and spirit of the principles of the presently disclosed embodiments.
DETAILED DESCRIPTION
[0025] Methods of treating psychiatric or psychological disorders using light energy are disclosed herein. The methods of the present disclosure may include using lateral visual field stimulation (LVFS) to determine which hemisphere of the brain requires treatment. Light energy may be applied to the chosen hemisphere to treat the psychological disorder. In an embodiment, the light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychological disorders.
[0026] As used herein, the terms “depression,” “depressive disorder,” “dysthymic disorder,” “major depressive disorder” and “unipolar depression” refer to a DSM-IV definition of depression.
[0027] As used herein, the term “psychiatric disorders” refers to any psychiatric disorders including, but not limited to, depression, attention deficit disorder, schizophrenia, bipolar disorder, anxiety disorders, alcoholism, eating disorders such as anorexia and bulimia, phobias, Asperser's syndrome, dissociative disorders, insomnia, and borderline personality disorder. The DSM-IV definition applies to these psychiatric disorders. Psychiatric disorders also include substance abuse disorders (i.e., alcohol abuse or opiate dependence or abuse) caused either by depression or not caused by depression, persistent anxiety, anxiety attacks, feelings of panic, fears of social contacts, nightmares, flashbacks, obsessive thoughts, compulsive behavior, attention disorder, sexual problem, and irrational thinking.
[0028] As used herein, the term “co-morbid” or “co-existent” refers to any psychiatric disorders that exist in addition to a primary disease or disorder, such as depression.
[0029] As used herein, the term “transcranial” refers to a procedure that is performed through the cranium, or the skull that covers and protects the brain. Transcranial refers to a noninvasive method that delivers energy to the neurons of the brain. Transcranial therapy can cause activity in specific or general parts of the brain with minimal discomfort, allowing the functioning and interconnections of the brain to be studied and/or treated. The light device is held on the scalp, no actual contact is necessary, and the energy passes through the skull and into the brain. Small induced currents can then make brain areas below the light device more or less active, depending on the settings used.
[0030] As used herein, the term “treat”, “treating” or “stimulating” refers to enhancing a person's positive outlook or suppressing a person's negative outlook. This may refer to a person's psychological well-being, including but not limited to their emotional, cognitive, and motivational states. Those persons who are successfully treated can find more appreciation for life, for themselves (improved self-esteem), their work, and their personal relationships.
[0031] Well-being refers to a state of wellness of body, mind and soul, where all are in a state of health, the individual is happy and prospering. Well-being describes the overall welfare of an individual including a good or satisfactory condition of existence. Well-being is a state characterized by health, happiness, and prosperity.
[0032] Psychiatric disorders include, but are not limited to, depression, attention deficit disorder, schizophrenia, bipolar disorder, anxiety disorders, alcoholism, eating disorders such as anorexia and bulimia, phobias, Asperser's syndrome, dissociative disorders, insomnia and borderline personality disorder. One prevalent psychiatric disorder is depression. Depression may be defined as a combination of sadness, loss of energy, feelings of hopelessness, difficulty concentrating, insomnia, and irritability. The National Comorbidity Survey reported that 46% of men and 58% of women have suffered in their lifetime at least a two-week period in which they experienced a persistent depressed mood. Major depression has a lifetime prevalence of about 16%, and it is estimated that by 2020, it will be the second greatest contributor to the impairment of global health. A recent Australian survey reported that anxiety disorders were the most common mental disorder with a lifetime prevalence of 26%.
[0033] In psychiatry, the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) is a manual published by the American Psychiatric Association (APA) that includes all currently recognized mental health disorders. In the DSM-IV, there are two diagnoses for depression, Major Depression and Dysthymic Disorder, as described below.
[0034] Major Depressive Disorder is characterized by one or more Major Depressive Episodes (i.e., at least 2 weeks of depressed mood or loss of interest accompanied by at least four additional symptoms of depression). Dysthymic Disorder is characterized by at least 2 years of depressed mood for more days than not, accompanied by additional depressive symptoms that do not meet criteria for a Major Depressive Episode.
[0035] Criteria for Major Depressive Episode include:
[0036] A. Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Note: Do not include symptoms that are clearly due to a general medical condition, or mood-incongruent delusions or hallucinations.
(1) depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad or empty) or observation made by others (e.g., appears tearful). Note: In children and adolescents, can be irritable mood.
(2) markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation made by others)
(3) significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. Note: In children, consider failure to make expected weight gains.
(4) insomnia or hypersomnia nearly every day
(5) psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down)
(6) fatigue or loss of energy nearly every day
(7) feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick)
(8) diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others)
(9) recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide
[0046] B. The symptoms do not meet criteria for a Mixed Episode.
[0047] C. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
[0048] D. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism).
[0049] E. The symptoms are not better accounted for by Bereavement, i.e., after the loss of a loved one, the symptoms persist for longer than 2 months or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation.
[0050] Diagnostic criteria for Dysthymic Disorder include:
[0051] A. Depressed mood for most of the day, for more days than not, as indicated either by subjective account or observation by others, for at least 2 years. Note: In children and adolescents, mood can be irritable and duration must be at least 1 year.
[0052] B. Presence, while depressed, of two (or more) of the following:
(1) poor appetite or overeating
(2) insomnia or hypersomnia
(3) low energy or fatigue
(4) low self-esteem
(5) poor concentration or difficulty making decisions
(6) feelings of hopelessness
[0059] The DSM-IV (1), the International Classification of Diseases (ICD-9-CM)(2), and as described in The Comprehensive Textbook of Psychiatry (3), thus, define depressive disorders, which in the DSM-IV and the ICD-9-CM are given specific diagnostic codes: major depression is 962.3 and dysthymia is 300.4. In distinction from the depressive disorders, the DSM-IV, ICD-9-CM, the Comprehensive Textbook of Psychiatry, and the accepted practice in the profession (4) consider other disorders as separated and distinct psychiatric diagnoses. The DSM-IV list of major categories is as follows:
Disorders Usually First Diagnosed in Infancy, Childhood, or Adolescence
Delirium, Dementia, and Amnestic and Other Cognitive Disorders
Mental Disorders Due to a General Medical Condition
Substance-Related Disorders
Schizophrenia and Other Psychotic Disorders
Mood Disorders
Anxiety Disorders
Somatoform Disorders
Factitious Disorders
Dissociative Disorders
Sexual and Gender Identity Disorders
Eating Disorders
Sleep Disorders
Impulse-Control Disorders Not Elsewhere Classified
Adjustment Disorders
Personality Disorders
Other Conditions That May Be a Focus of Clinical Attention
[0077] The depressive disorders are listed under Mood Disorders. The profession considers other diagnostic categories distinct and separate from depressive disorders in terms of diagnosis, treatment, clinical course, symptoms, genetics, and brain pathophysiology. For example, electro-convulsive therapy is commonly used to treat major depression, but is not used for childhood disorders, dementia, mental disorders due to a general medical condition, substance-related disorders, anxiety disorders, somatoform disorders, factitious disorders, dissociative disorders, sexual and gender identity disorders, eating disorders, sleep disorders, impulse-control disorders, adjustment disorders or personality disorders. Benzodiazepams such as diazepam or klonazepam are common treatments for anxiety disorders but are likely to make depressed patients more depressed. Schizophrenia is treated with antipsychotic medications that, with a few exceptions, are only used to treat psychotic patients. Buprenorphine is used to treat opiate dependence, but is not approved for any other diagnosis. Disulfiram is used only in the treatment of alcohol dependence.
[0078] Depression can run in families, and usually starts between the ages of 15 and 30. It is much more common in women. Women can also get postpartum depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder. There are effective treatments for depression, including antidepressants and talk therapy. Many depressed people do best by using both.
[0079] Depression is considered separate and distinct from other psychiatric or psychological disorders. Depression by any definition does not encompass most psychological disorders. For example, people who are diagnosed with schizophrenia have delusions and/or hallucinations, and have a deterioration of their personality rendering them almost always incapable of complex work or sustained relationships. A person with an anxiety disorder will suffer excessive apprehension and worry with heightened arousal, but will not feel sad or hopeless unless he suffers, in addition, a coexisting depressive disorder. A person who abuses substances will usually not also suffer anxiety or depression, although he may have a dual diagnosis in which both a substance abuse disorder and another disorder such as an anxiety disorder or a depressive disorder are also present. 47% of patients diagnosed with schizophrenia also have a substance abuse disorder.
[0080] Each of the diagnostic entities in the DSM-IV are supported not only by clinical descriptions, but also by biological studies that use electroencephalography (EEG), magnetoencephalograpy (MEG), functional magnetic resonance imaging (fMRI), evoked potentials, electrodermal activity, biochemical markers (catecholamines and catecholamine metabolites; indoleamines and indoleamine metabolites, acetylcholine, histamine, aminoacids, melatonin, prostaglaindins, opoid petptides, neupropeptides, enzymes, receptor densities), psychoimmunological markers, genetic markers, and animal models.
[0081] By modern scientific techniques, depressive disorders and other DSM-IV disorders can be distinguished from each other. For example, as reviewed in the textbook, Current Diagnosis and Treatment: Psychiatry by Loosen and Shelon, antidepressant treatments (including pharmacotherapy and electroconvulsive therapy [ECT]) cause desensitization of the norepinephrine receptor—coupled adenylate cyclase system in brain, which is linked to a decrease in the density of adrenoceptors in the brain. This decrease in receptor sites paralleled the delayed onset of action common to all antidepressants. Further, depression is associated with the integration of multiple intracellular signals that regulate neuronal response (i.e., changes in G protein, cyclic adenosine monophosphate, or protein kinase and the induction of gene transcription). These intracellular signals ultimately affect the expression of specific genes. It is these abnormalities of intracellular signal transduction and/or gene expression that underlie much of the physiology of depression. Other neurotransmitters (e.g., acetylcholine, gamma amino butyric acid, melatonin, glycine, histamine), hormones (e.g., thyroid and adrenal hormones), and neuropeptides (e.g., corticotropin-releasing hormone, endorphins, enkephalins, vasopressin, cholecystokinin, substance P) also play significant roles in the physiology of depression.
[0082] In depression, functional imaging studies most consistently demonstrate a decreased prefrontal cortex (PFC), especially left PFC, blood flow. These findings correlate with severity of illness and cognitive impairment. Functional imaging in depressed patients also show basal ganglia abnormalities, involving decreased blood flow and metabolism as well as increased activity of amygdala. In major depression, other neuroimaging studies show abnormalities in the hippocampus, cingulate, and related parts of the striatum and thalamus. Together data offer a neural model for depression in which dysfunction of limbic, striatal, and PFC structures impair the modulation of the amygdala/hippocampus complex and lead to abnormal processing of emotional stimuli. Depression also tends to be associated with lesions in the left frontotemporal or right parieto-occipital regions.
[0083] Many patients with dysthymic disorder have brain wave (EEG) abnormalities that mimic those found in major depression such as reduced REM latency, increased REM density, reduced slow-wave sleep, impaired sleep continuity. Patients with dysthymia who have these EEG abnormalities more frequently have a positive family history for major depression. They also respond better to antidepressant medications.
[0084] Anxiety disorders have scientific findings that differentiate them from depression and other psychiatric or psychological disorders. In patients with anxiety disorders functional neuroimaging shows abnormalities during symptom provocation tests, in the limbic, paralimbic and sensory association regions.
[0085] For anxiety there is a general theory of a neural behavioral-inhibition system. This system evaluates stimuli to attempt to determine their level of dangerousness and simultaneously in response produce behavioral inhibition and increase arousal and attention. Antianxiety drugs inhibit brain areas involved in these responses. From animal studies using pharmacological agents and/or brain lesions, anxiety is associated with several interconnected anatomical areas. Sensory stimuli that are interpreted as dangerous activate the hippocampus, especially the entorhinal cortex, which secondarily induces habituation by actions on the lateral and medial septal areas, which then stimulate the cingulate which induces behavioral inhibition. Several specific neurotransmitter systems influence this anxiety mechanism, including noradrenergic activity of the locus coeruleus, serotonergic systems originating in the raphe, and by widespread GABAA-receptor activity (which are the main locus of activity of the benzodiazepines).
[0086] Stimuli that are interpreted as acute threats activate the “fight or flight” response, which is mediated especially by the locus coeruleus and the amygdala. The amygdala encodes fearful memories and aversive conditioning and participates in the acute fear and negative anticipation that we call anxiety.
[0087] Further, intense anxiety stimulates the sympathetic nervous system via the locus coeruleus, and this induces tachycardia, tremor, and diaphoresis. The frontal cortex becomes aware of the anxiety and induces behavioral responses which are attempts to improve survival, but which often cause more harm and increase danger. The cingulate, in anxiety disorders, attempts to improve the communication between the cortex and the subcortical areas.
[0088] Patients with a panic disorder can have a panic attack induced by intravenous sodium lactate or inhalation of 5-35% CO2. This will not affect individuals who do not suffer a panic disorder. These agents activate the locus coeruleus. There is new evidence that 5-HT1A-receptor binding is reduced in some patients with panic disorder.
[0089] In an embodiment, the methods of the present disclosure can be used to diagnose and treat the human brain for psychological, psychiatric, depressive, neurological, general well-being and other conditions. In an embodiment, the methods of the present disclosure may include the use of a light treatment device to diagnose and treat depression. In an embodiment, the methods of the present disclosure may be used to diagnose and treat psychiatric disorders other than depression including, but not limited to, attention deficit disorder, schizophrenia, bipolar disorder, anxiety disorders, substance abuse disorders such as alcohol abuse and drug abuse, eating disorders such as anorexia and bulimia, phobias, Asperser's syndrome, dissociative disorders, insomnia, borderline personality disorder or combinations thereof. In an embodiment, the methods of the present disclosure may be used to diagnose and treat other psychiatric or psychological disorders including, but not limited to, persistent anxiety, anxiety attacks, feelings of panic, fears of social contacts, nightmares, flashbacks, alcohol or drug abuse, obsessive thoughts, compulsive behavior, attention disorder, sexual problem, eating disorder such as anorexia, bulimia or obesity, irrational thinking, or combinations thereof. In an embodiment, the methods of the present disclosure may be used to diagnose and treat psychiatric disorders that are co-morbid or co-existent with depression. In an embodiment, the methods of the present disclosure may be used to diagnose and treat more than one psychiatric disorder at a given time. For instance, the method may diagnose and treat a patient having both depression and attention deficit disorder or a patient having both anorexia and insomnia. In an embodiment, the methods of the present disclosure may be used to benefit persons who do not have any psychological disorders. For patients without any of the above psychological disorders, the methods of the present disclosure may help improve their psychological well-being and enhance their positive outlook. These patients can find more appreciation for life, for themselves (improved self-esteem), their work, and their personal relationships. The methods of the present disclosure may improve patient self-confidence, positive disposition, interpersonal relationships, and/or quality of life.
[0090] A recently published study was conducted of an open clinical trial of the use of transcranial near infra-red light to treat 10 psychiatric patients (5 males) with a current major depressive disorder with a comorbid anxiety disorder, including 3 with a history of Post-Traumatic Stress Disorder. Schiffer F, Johnston A L, Ravichandran C, Polcari A, Teicher M H, Webb R H, Hamblin M R. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behavioral and Brain Functions. 2009 Dec. 8; 5:46.
[0091] Seven of these patients had a past history of opiate dependence (6 patients) and one had a history of alcohol dependence. The patients were allowed to continue their usual psychiatric treatments, but were asked, if possible to not alter their on-going treatments. None altered their treatments from 2 weeks before the NIR-PBM or during the 4-week follow-up.
[0092] As a baseline measure each patient had a Standardized Clinical Diagnostic Interview to determine their diagnosis. The patients also had their hemispheric emotional valence measured using lateral visual field stimulation (LVFS), which includes having a patient look out of one side of taped safety goggles to allow their vision to be restricted on either the left or the right lateral visual field. Earlier studies found that LVFS can induce EEG, ear temperature, and fMRI changes. These results indicate that looking out the right visual field activates the left hemisphere of the brain and that looking out of the left visual field activates the right hemisphere of the brain.
[0093] Earlier studies further reported that looking out of one lateral visual field for a minute or more can induce a personality alteration such that one side (left or right) in 80% of patients will induce a more mature personality while looking out of the other visual field will stimulate a personality that is more immature and more negatively effected by past traumas. By measuring the affective state of the patient while he or she looks out of both visual fields we can calculate a hemispheric emotional valence which indicates the degree to which either the left or the right cerebral hemisphere is mature and healthy or immature and neurotic. Some studies suggest that using the patient's hemispheric valence might guide the application of lateralized treatments to the brain for psychiatric conditions as well as help in the evaluation of data from experiments treating one cerebral hemisphere. For example, two similar but different studies reported that the baseline hemispheric emotional valence predicted which patients would respond to left-sided transcranial magnetic stimulation, an FDA approved treatment for depression that applies a powerful electromagnet to the left-side of the head. Both studies suggested that treating a patient who has a positive hemispheric valence in his left hemisphere (the treated hemisphere) will do well, but that patients who have a negative hemispheric emotional valence in their left hemisphere (the treated hemisphere) will not do well.
[0094] As another baseline measure each patient was given a Hamilton Depression Rating Scale, a Hamilton Anxiety Rating Scale, and a Positive and Negative Affect Scale. The two Hamilton scales are used to measure changes in depression and in anxiety from a treatment over at least a week. The Positive and Negative Affect Scale is used to measure immediate changes in mood following a treatment.
[0095] Each patient's cerebral blood flow in the frontal poles of their brain on both the left and right sides was measured using, for instance, a commercial device. The patients then received 4 treatments. Two treatments were placebo treatments, with the near infrared light turned off, one treatment was over the left side of the forehead and another treatment was over the right-side. The two active treatments consisted of a 4-minute treatment with near infrared light at 240 mW, one on the left-side of the forehead and the other on the right-side. Patients were unable to detect whether the light was on or off, and so the light off condition acted as a placebo condition.
[0096] Immediately after each treatment (left-side “on”, left-side “off”, right-side “on”, right-side “off” we measured the patient's affective state with the Positive and Negative Affective Scale. During each treatment we measured the cerebral blood flow in the left and in the right frontal pole of the patient's brain. At two weeks post treatment and at four weeks post-treatment we repeated both of the Hamilton scales.
[0097] The study revealed several findings. First, following each of the 4 treatment conditions, the Positive and Negative Affective Scale scores showed an improvement if the side with a positive hemispheric emotional valence was treated but a worsening in the measured affective state if the hemisphere with a negative hemispheric emotional valence were treated. Second, the study found when the left side of the forehead was treated with the light on, the frontal pole blood flow was 0.65±sd 0.08, compared to 0.06±sd 0.05 when the left-side was treated with the light off, placebo condition.
[0098] The study also revealed that at 2-weeks post treatment (all 4 treatment conditions were given on the same day) there was a dramatic improvement in both the Hamilton Depression Rating Scale and in the Hamilton Anxiety Rating Scale. Sixty percent of the 10 patients went into a remission defined as a Hamilton Depression Rating Scale score of <10 at 2-weeks post treatment. For the Hamilton Anxiety Rating Scale, 70% achieved a remission at this criteria. These results compare favorably other treatments for depression or anxiety disorders such as cognitive behavior therapy of 30 weeks, serotonin reuptake inhibitors for 8 weeks, a course of transcranial magnetic stimulation or a course of electro-convulsive shock therapy as discussed in our publication. Since the sample of patients included those suffering from major depression, a generalized anxiety disorder, post-traumatic stress disorder, and recent substance abuse, this NIR-PBM treatment might be suitable for additional diagnostic groups.
[0099] The study further showed that the outcomes on the Hamilton Anxiety Rating Scale were predicted by an interaction between the individual patient's hemispheric emotional valence times the increase in blood flow in the frontal pole on the side of the positive hemispheric valence. (See FIG. 8)
[0100] As a result, the study found that bilateral NIR-PBM treatments led to highly significant improvements 2 weeks post treatment. The study also found that immediately after treatment, patients did well when the hemisphere with a positive valence was treated and poorly when the hemisphere with a negative valence was treated. From this observation, it is likely that treating only the side with a positive hemispheric valence might give better results than the bilateral treatment results at 2-weeks post treatment. The location of treatment is likely also important. Treating over the upper side of the forehead, in an embodiment, is likely to activate the hemisphere while treating over the area of the forehead over the eye may have an inhibitory effect.
[0101] The study results are not likely due to placebo effects for several reasons. First, placebo effects are usually on the order of a 20% improvement and our improvement was on the order of 50 to 60%. Second, cerebral blood flow increased when the NIR-PBM was “on” versus the placebo “off” condition. Patients could not determine whether or not the light was on or off. Third, immediately following the treatments, the patients improved to a greater extent when the hemisphere with a positive hemispheric emotional valence was treated. And finally, the Hamilton Anxiety Rating Scale scores were predicted by the product of the lateralized cerebral blood flow and the hemispheric emotional valence.
[0102] The methods of the present disclosure can be used with light treatment devices known in the art that deliver light energy for diagnosis and treatment of the human brain for psychological, psychiatric, depressive, neurological, general well-being and other conditions. In one embodiment, the methods of the present disclosure may include the use of lateral visual field stimulation (LVFS) in conjunction with light treatments to help treat a variety of psychiatric disorders or psychological conditions. The brain is at its core an information processor. It takes sensory inputs, interprets them, and decides on a response. A computer is also an information processor that takes inputs and creates responses or outputs. The computer uses transistor states to code information; the brain uses neural firing patterns or biological neural networks to code its information. Like a computer the brain uses parallel and serial processing, and different biological neural networks in the brain operated somewhat independently, but, like a computer in a network, are related to other biological neural networks. The brain's neural networks have hierarchical arrangements. For example, sensory association areas of the brain have biological neural networks that process information from several primary sensory areas (perhaps for hearing, sight, and touch). The biological neural networks in the sensory association areas will relate to higher order association areas in the frontal cortices whose biological neural networks integrate the sensory information with information from other biological neural networks having to do with other functions such as emotion or memory. Each neural network processes information, and as such is a mini-brain, which combines with other biological neural networks to create higher levels of function and eventually create a mind with perceptions, emotions, motivations, and actions or behaviors. A person can have a dominant high-level set of biological neural networks that support his dominant personality, but he may have competing high-level sets of neural networks that support a personality with somewhat different perceptions, emotions, motivations, actions or behaviors. These high level biological neural networks appear to have a relationship with one or the other of the two cerebral hemispheres of the brain. The neural networks associated with one hemisphere (either the left or the right) might be more affected by past traumas and have a more neurotic perception of the world. For example, someone who was bullied as a child, might as an adult, have high level neural networks that incorrectly perceive the world as hostile and threatening. That person may have another set of high level neural networks, associated with the other cerebral hemisphere, that are healthier and see the world (as it now actually is) as safe. Depending on which set of high-level neural networks is dominant at a particular time, the person will manifest a personality that is either troubled or is healthier (or some combination of the two).
[0103] Childhood traumas are almost always associated with biological neural networks that are associated with one hemisphere more than the other. Troubled biological neural networks may not be associated with only one hemisphere, but rather they may be associated more with one hemisphere over the other and once stimulated can take over the entire brain. Different set of neural networks can compete for dominance and when in control can use more and more of the brains neurons. In a computer, one program such as Word uses the same transistors that a different program such as Excel uses. The allocation of neurons within the brain may be determined by the struggles between competing sets of biological neural networks.
[0104] Each diagnostic entity is manifested by different configurations of biological neural networks involving different brain locations and different neural transmitters and so are distinct entities as described above. However, each entity may involve a healthier and a more pathological set of neural networks that are associated each with one of the two cerebral hemispheres. Which hemisphere is associated with the more pathological neural networks has to be determined for each individual patient. This may refer to a hemispheric valence. The hemisphere with the healthier neural networks is said to have a more positive hemispheric emotional valence. The other cerebral hemisphere is thought to have a more negative hemispheric emotional valence.
[0105] This explanation is based mainly on two observations. The first is that we know that the eyes in all people are connected to the brain so that images projected to the left visual field are sent first to the right cerebral hemisphere. The information can then be sent via the corpus callosum to the opposite hemisphere, but in patients in whom the corpus callosum has been severed as a treatment for epilepsy, the image is seen only by one hemisphere. This discovery led to the “Split-brain Studies” for which Roger Sperry won the Nobel Prize. We found that having patients limit their vision to either the left or right lateral visual field while in an fMRI scanner led to the observation illustrated in FIG. 2 that when the patients looked out of their right lateral visual field the blood flow (and presumably their brain activity) in their left brain was dramatically increased. The opposite occurred when the subjects looked out of the left lateral visual field.
[0106] In an embodiment, based on earlier publications, having a person look out of one lateral visual field and then the other could cause dramatic changes in the patients' psychological state. About 60% of patients may feel differently when they look out of one visual field versus the other and about 30% have extreme responses. About 85% of patients with severe symptoms will have an extreme response. An example of an extreme response is the following: a patient who is a veteran of the war in Viet Nam looked out of his right lateral visual field and saw a large plant behind me and became alarmed. He said, “That plant looks like the jungle!” I asked him quickly to look out of the left lateral visual field and he said, “That's a nice looking plant.” He was obviously distressed when looking out the right lateral visual field and was relaxed and calmed when looking out of the left lateral visual field. The side in which the patient gets upset is consistent for that patient, but for another given patient the side that is upsetting can be either the left or right side. Patients with post-traumatic stress disorder, about 65% of the time, feel more distressed when they look out of the right visual field (left brain is more distressed). Patients with major depression about 65% of the time feel more distressed when looking out of the left lateral visual field.
[0107] LVFS can be used to guide the placement of light treatments. In an embodiment, LVFS may be used to activate positive neural networks and negative neural networks. The positive neural networks and the negative neural networks in the brain may be associated with positive or negative outlooks on the world, respectively. In an embodiment, traumatic experiences may be associated with specific neural networks that are in some way associated with one hemisphere. Treatment of psychological conditions may include treating these negative neural networks, either through education, suppression, by enhancing the positive neural networks associated with the hemisphere with a positive HEV, psychotherapy, deep brain stimulation, certain psychotropic medications, unilateral ECT, transcranial magnetic stimulation (TMS) or by a combination of methods. In an embodiment, near infrared (NIR) treatments may be used to enhance the positive hemisphere, suppress the negative, and to support the teaching or healing of the negative neural networks so that the trauma can be tolerated, grieved and recovered from. In another embodiment, NIR treatments can be combined with other treatments.
[0108] In an embodiment, the methods of the present disclosure may include the use of glasses for the LVFS treatment. As shown in FIG. 1, glasses, such as safety glasses or goggles, are taped or covered so that they permit vision to only one lateral visual field at a time. The patient is asked to look to one side and to fixate the center of his vision on the edge of the tape so that he or she is looking out of the lateral half of one eye. Vision from the other eye is occluded by the tape on the other side. While looking out of the specific visual field, the patient is asked to look at a photograph of a man or woman with a mildly angry facial expression. After 45 seconds, he or she is asked to verbally rate his or her present feelings for each of 10 affects from Positive and Negative Affect Scale (PANAS), from none to extreme on a 5 point scale. Following the PANAS measurements, the patient is asked to rest for 1 minute looking straight ahead so that vision from both eyes is occluded. The patient is then asked to repeat the procedure by looking out of the second visual field.
[0109] The PANAS has 5 positive affects including alert, inspired, determined, attentive, active and 5 negative affects including upset, hostile, ashamed, nervous, afraid. For each visual field, the sum of the scores on the 5 negative affects is subtracted from the scores from the 5 positive affects and the difference is the PANAS score. The score measured when the person looks out of the right lateral visual field (RVF) is subtracted from the score measured when the person looks out of the left lateral visual field (LFV). The LVF is indicative of the state of the right hemisphere since the connection between the medial retinas and the cerebral hemispheres are crossed. Since a more positive PANAS score indicates more positive affect, we assign a value for the person's HEV according to the formula: LVF PANAS score—RVF PANAS. A positive score suggests that the right hemisphere has a more positive HEV. Research studies show that LVFS offers a good indication that the left and right cerebral hemispheres are generally associated with different emotional valences such that one hemisphere (either left or right) is associated with a more positive outlook on the world (positive hemispheric valence) and the other a more negative outlook on the world (negative hemispheric valence).
[0110] A person's personality and some of the person's psychological characteristics may be affected by which hemisphere, right or left hemisphere, dominates. The eyes are connected to the brain so that vision to the left side of a person goes first to the opposite (right) hemisphere and vision to the right side of a person goes first to the left hemisphere. One hemisphere can be stimulated over the other by restricting vision to a portion of the retina of an eye that is connected to a particular hemisphere of the brain. For instance, LVFS has been shown by fMRI to induce a very large increase in brain activity in the hemisphere opposite the visual field, when the subject looked out of the left visual field (LVF) and the right visual field (RVF). FIG. 2 shows images of the brain having different activity in the left and right cerebral hemispheres after looking out of the left and right lateral visual fields. FIG. 2A shows brain activity after looking out of the left half of the left eye. FIG. 2B shows brain activity after looking out of the right half of the right eye. As an example, a person looking out of one visual field might see another person as very critical of him and he might feel very critical of himself. Looking out the opposite visual field he is apt to see another person as quite approving of him and he is apt to see himself positively.
[0111] In an embodiment, the PANAS score may be used to determine which hemisphere of the brain to treat for a psychological disorder. Treating, or stimulating, one hemisphere of the brain at a time may cause certain changes in the psychological state of a person. These changes include, but are not limited to, a more positive outlook and a reduction in a negative outlook. In one embodiment, applying light over the upper side of the forehead (over the dorsolateral prefrontal cortex) will stimulate the hemisphere on that same side. In an embodiment, stimulating the brain in the medial pre-frontal cortex (stimulating transcranially on the forehead just above the eye on one side will inhibit the limbic system on that same side. In some embodiments, applying light on the forehead over the eye is likely to be emotionally inhibitory. In other embodiments, applying light over the upper side of the forehead (i.e., over the dorsolateral prefrontal cortex) over the hemisphere with a positive valence is likely to be helpful as would be treating over the medial pre-frontal cortex of the other hemisphere (with a more negative valence) to inhibit the limbic system of the hemisphere with a negative valence. With clinical practice, one could expect to improve this art by learning better locations and parameters for light treatments.
[0112] In an embodiment, diagnosing and treating one hemisphere of the brain may only cause changes in the psychological state of a person having a positive HEV. For example, treating the left hemisphere may benefit those patients who had a positive left hemispheric emotional valence (HEV), but not those with a negative left HEV. On the other hand, treating the right hemisphere may benefit those patients who had a positive right hemispheric emotional valence (HEV), but not those with a negative right HEV. In an embodiment, treating one hemisphere of the brain may only cause changes in the psychological state of person having a negative HEV. For example, treating the left hemisphere may benefit those patients who had a negative left hemispheric emotional valence (HEV), but not those with a positive left HEV. On the other hand, treating the right hemisphere may benefit those patients who had a negative right hemispheric emotional valence (HEV), but not those with a positive right HEV. In an embodiment, treating one hemisphere of the brain may cause changes in the psychological state of person having an either a positive HEV or a negative HEV. In an embodiment, diagnosis and treatment of a psychological disorder may be specific for each particular disorder. For example, treatment of anorexia may require treatment of the hemisphere with a positive HEV while treatment of insomnia may require treatment of the hemisphere with a negative HEV.
[0113] In an embodiment, the methods of the present disclosure may include using light energy to treat a hemisphere of the brain. In an embodiment, the light energy may include near infrared light (NIR). During this procedure, subjects can wear protective eyewear to prevent the light to be shined into their eyes. NIR light may, in an embodiment, be applied using Photobiomodulation (PBM) in the form of an LED, as shown in FIG. 3. FIG. 4 shows a close up of the PBM device. FIG. 5 shows a control unit of the PBM device. The control unit may contain a power supply. The power supply may be in the form of a battery or it may be connected to a power outlet. In an embodiment, the control unit may include at least one socket to connect with a LED. In an embodiment, one socket and one LED may be used to treat one location on a patient's head at a given time. In an embodiment, more than one LED can be used to treat more than one location on a patient's head at a given time. For example, in stroke patients, NIR may be used over the entire head. A knob is situated on the control unit to control the voltage to the LED. An increase in the voltage may be associated with an increase in the light being delivered.
[0114] In an embodiment, NIR light may be applied at a distance of about 0 to 1000 mm from the skin. In an embodiment, NIR light may be applied at a distance of about 4 mm from the skin. Placing the NIR light at a distance of about 4 mm from the skin at a power density of about 250 mW/cm<2 >allows an amount of NIR light and intensity to be directed at a person's brain without causing harm to the brain during a 4-minute treatment at a given site. This dose may be safely delivered to other sites on the head in the same treatment setting. This dose could be increased as long as it is below the ANSI standard of about 320 mW/cm<2 >on the skin at each site. It should be noted that the intensity of the NIR light increases as the NIR light approaches the skin and decreases in intensity by the square of the distance as the NIR light is moved away from the skin. One reason for choosing the distance of about 4 mm from the skin at a power density of about 250 mW/cm<2 >is that the closer to the skin the more likely the LED will emit heat that cannot be dissipated by the heat sink and fan. If the patient can detect heat, placebo controlled studies may not be conducted as the patient may know whether the LED light was on or off. Also, the heat from the LED might cause the patient to feel pain the closer the LED is to the patient. Additionally, too much light, without heat, can cause damage to the skin. There is a conservative standard for the permissible amount of light (photons) at near infrared frequency of 810 nm, called the ANSI standard, as noted above, and studies with NIR light below that standard will not cause any harm to the patient.
[0115] During treatment, the light treatment device may be pulsed, or the light treatment may be continuously applied. In certain embodiments, the light treatment device may be combined with other types of treatments for an improved therapeutic effect. Treatment can include directing light through the scalp of the patient to a target area of the brain concurrently with applying an electromagnetic field to the brain. The light may be applied with a desired power density and with a desired electromagnetic field strength at the target area. In an embodiment, methods of treating a psychiatric disorder may include non-invasively irradiating at least a portion of a patient's brain with light energy having an efficacious power density and wavelength, sufficient to cause a neurotrophic effect and/or regulation of neurotransmitters. In another embodiment, methods of treating a psychiatric disorder may include non-invasively irradiating at least a portion of a patient's brain with light energy having an efficacious power density and wavelength, sufficient to cause a neurotrophic effect and/or regulation of neurotransmitters, and delivering the light energy for one or more treatment periods occurring over the course of at least one week, each treatment period having a duration of at least about 1 minute.
[0116] In an embodiment, the NIR light may be pulsed when applied to the skin. Pulsing the NIR light can allow the use of a more intense light and yet remain below the ANSI standard. Pulsing the NIR light may be used to entrain the brain and thereby affect the state of the brain. A faster entrainment can increase brain activity, and a slower entrainment can decrease brain activity.
[0117] The light output may be continuously applied at about 250 mW/cm<2 >at a wavelength of about 810 nm with a full width half maximum of about 40 nm. In an embodiment, the NIR light may be directed at a person's brain for about 4 minutes (total delivered fluence per spot of 60 J/cm<2>). In an embodiment, the procedure with the NIR light may be repeated at at least one other site on the forehead. In an embodiment, the NIR light may penetrate the dura, or the outermost of the three layers of the meninges surrounding the brain, at about 3.7%. In accordance with a penetration of about 3.7%, approximately 2.1 J/cm<2 >of fluence is delivered to each of the treated areas of the brain. It should be noted that the level of light exposure is below the ANSI standard of 320 mW/cm<2>. The level of light exposure either to the skin (power density of 250 mW/cm<2 >and total fluence of 60 J/cm<2>), to the surface of the brain (power density of 9.5 mW/cm<2 >and total fluence of 2.1 J/cm<2>) and to each of the 2 treated areas of the forehead poses no significant risk to the skin or the brain. It should be noted that while described above with a specific frequency, the invention of the present disclosure could also use a frequency from about 300 nm to about 1500 nm. Furthermore, the present invention can use any source of light, whether low level laser or LED, so long as its duration and intensity are below the ANSI standard of 320 mW/cm<2 >on the skin.
[0118] The methods of the present disclosure may affect blood flow within the brain. Blood flow in the brain can be measured in left and right frontal poles by NIRS, by a blood flow monitoring device, such as a Somanetics INVOS system, modified by Somanetics to provide total hemoglobin (cHb). In an embodiment, the blood flow monitoring device uses a low power NIR LED. The blood flow monitoring device has no effect on the brain. The blood flow monitoring device measures the amount of blood in the brain once a second. In an embodiment, the Somanetics devices measures oxy- and deoxy-hemoglobin. The blood flow monitoring device poses no harm or discomfort to subjects and allows subjects to have relatively free movement. The blood flow monitoring device can be used to monitor cHb in the left and right frontal poles during PBM. Since the PBM used in an embodiment of the present disclosure is a continuous wave, the light from the PBM is not detected by this NIRS device because it has a proprietary mechanism for excluding continuous light so that sunlight does not affect the device's pulsed photon emitter. It should be noted that the Somanetics device is FDA approved, is commercially available, and is used throughout the world in hospital settings to monitor cerebral perfusion.
[0119] In an embodiment, cHb can be measured by NIRS during treatments at at least one point. In an embodiment, there may be a correlation between NIR and improved cHb and mood. For example, there may be greater total (left plus right) cHb during NIR on versus off as shown in FIG. 6. FIG. 7 shows that there was a significantly more positive affect when the hemisphere with a positive HEV was treated with NIR-PBM and a significantly more negative affect after a hemisphere with a negative HEV was treated. In FIG. 7, “matched” refers to treating the hemisphere with a positive HEV and “unmatched” refers to treating the hemisphere with a negative HEV. PANAS scores declined when the negative hemisphere was treated. Thus, in a blind, placebo-controlled secondary study, the PANAS scores improved on the PANAS items, following NIR treatments to the hemisphere with a more positive HEV. The PANAS scores correlated very highly with the HEV values times agreement (1) or disagreement (-1) with the side treated.
[0120] The increase in cHb with NIR suggests that the NIR treatment is affecting the brain. The improvement in PANAS immediately following the treatment may indicate that this effect on the brain likely relates to the alterations in affect. FIG. 8 shows that at 2-weeks post treatment, a decrease in anxiety (as measured by the Hamilton Anxiety Rating Scale) was related to the patient's baseline HEV and cerebral blood flow (CBF). In an embodiment, patients with a left negative HEV and an increase in right frontal CBF had less anxiety. In an embodiment, patients with a right negative HEV and an increase in left frontal CBF had less anxiety. Thus, patients who had an increase in blood flow in their positive hemisphere did better at 2-weeks post treatment. If a person has a negative side, increasing the blood flow on the opposite side can have a beneficial effect at 2-weeks post treatment. The fact that the outcomes at 2-weeks were dependent in regression models on the baseline HEV value is consistent with the fact that right hemisphere is often associated with a positive HEV (in opposition to the popular notion that negative affect and/or cognition are associated always with the right hemisphere) and that knowing a patient's HEV can enlighten data reduction and guide treatment. Cerebral blood flow correlates with brain activity in the front of the brain. Patients with a negative right HEV and an increased left CBF and patients with a negative left HEV and an increased right CBF may have significantly better outcomes in terms of their Hamilton Anxiety Rating Scale scores at 2-weeks post NIR treatment.
[0121] Several theories may help explain the possible correlation between NIR light and improved cHb and mood. NIR light is known to increase and/or stimulate mitochondrial ATP and nerve growth factors. This may be because the energy from the NIR light may be absorbed by the mitochondria, which are the energy production centers of the brain. Increasing and/or stimulating mitochondria and mitochondrial ATP may help stimulate the positive neural circuits or inhibit the negative neural circuits. It is further known that light therapies may promote wound healing or reduce the damage from strokes or heart attacks. Such studies were conducted in rats and rabbits.
[0122] It should be noted that patients who were treated bilaterally with the methods of the present disclosure experienced a remission of anxieties at a rate of about seventy percent. Remission refers to the state of absence of disease activity in patients with a chronic illness. Remission is measured using a rating scale where a score of greater than fifteen on the rating scale correlates to having an anxiety disorder and a score of ten or less on the rating scale correlates to being in remission and no longer manifesting an abnormal level of anxiety. Compared to other treatments, a remission rate of about seventy percent is very high. On the Hamilton Depression Scale there was an average percent decrease (percent less depression) of 54% 2-weeks after the single treatment, and on the Hamilton Anxiety Rating Scale, at 2-weeks post treatment, there was a percent decrease of 63%. These also compare well with other treatments. For example, studies have found that after 29 patients with an anxiety disorder were treated with cognitive behavioral therapy for 30 weeks, those 29 patients achieved a 51% reduction on the Hamilton Anxiety Rating Scale at the end of the treatment. In addition, studies have found that after 28 patients having an anxiety disorder were treated with short-term psychodynamic psychotherapy for 30 weeks, those 28 patients achieved a 43% reduction on this anxiety rating scale at the end of the treatment. In an embodiment, the methods of the present disclosure treats patients with light therapy for a total of about 8 minutes, is pain free, and without any observed side effects, and is generally inexpensive.
[0123] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy, including determining which hemisphere of the brain requires treatment using lateral visual field stimulation (LVFS) and applying light energy to the hemisphere of the brain to treat the psychiatric disorder other than depression. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0124] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient, including measuring a left hemispheric emotional valence and a right hemispheric emotional valence for a left hemisphere of the brain and a right hemisphere of the brain using a lateral visual field stimulation test; determining which hemisphere of the brain needs treatment; and applying light energy to the hemisphere of the brain to treat the psychiatric disorder co-morbid with depression.
[0125] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient, including measuring a left hemispheric emotional valence for a left hemisphere of the brain and a right hemispheric emotional valence for a right hemisphere of the brain using a lateral visual field stimulation test; determining the hemisphere of the brain in need of treatment; and applying light energy to the hemisphere of the brain to treat the psychiatric disorder co-morbid with depression.
[0126] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy including determining which hemisphere of the brain has a more positive affect using lateral visual field stimulation (LVFS) and applying light energy to the hemisphere with the more positive affect. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0127] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy including determining which hemisphere of the brain has a more negative affect using lateral visual field stimulation (LVFS) and applying light energy to the hemisphere with the more negative affect to improve its functioning. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0128] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy including determining which hemisphere of the brain has a more positive and negative affect using lateral visual field stimulation (LVFS); applying light energy to the hemisphere with the more positive affect; and applying light energy to the hemisphere with the more negative effect. In an embodiment, if both hemispheres have about equal levels of positive or negative affects, both hemispheres may benefit from the light energy. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0129] According to aspects illustrated herein, there is provided a method for treating psychiatric disorders using light energy including determining which hemisphere of the brain has a more negative affect using lateral visual field stimulation (LVFS); applying light energy to the hemisphere with the more negative affect; and increasing cerebral blood flow in the opposing hemisphere. In an embodiment, light energy may include near infrared light (NIR). The methods of the present disclosure may be used to treat a variety of psychiatric disorders.
[0130] According to aspects illustrated herein, there is provided method for treating a patient, including determining which portion of the brain of the patient requires treatment; and applying light energy to the portion to treat the patient. The light might be applied bilaterally over the left and the right dorsolateral pre-frontal corticies. In an embodiment, the treatment may be used to treat depression. In another embodiment, the treatment may be used to improve the well-being of the patient.
[0131] According to aspects illustrated herein, there is provided a method for treating a patient, including determining which portion of the brain needs treatment; and applying light energy to the portion of the brain to treat the patient. In an embodiment, the treatment may be used to treat depression. In an embodiment, the treatment may be used to cause an improvement in the well-being of the patient.
[0132] According to aspects illustrated herein, there is provided a method for treating a psychiatric disorder in a patient including applying light energy to a brain to treat the psychiatric disorder.
[0133] All patents, patent applications, and published references cited herein are hereby incorporated by reference in their entirety. It will be appreciated that several of the above-disclosed and other features and functions, or alternatives thereof, may be desirably combined into many other different systems or applications. Various presently unforeseen or unanticipated alternatives, modifications, variations, or improvements therein may be subsequently made by those skilled in the art
