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Stuff & Stuff
Sci-Tech News & Olds, &c...
February 2019

And the Ads
They're Cliqueing:
UPDATED 9 FEBRUARY
Thanks, DW (referral to rexresearch @ 19:00 re: Dr O.E. Wagner
/ W-Waves ):
https://www.youtube.com/watch?v=_NpqADtMhz4
Secret Antigravity Technology That Can
Levitate Any Known Object
David Wilcock
https://www.rt.com/news/450884-mice-bones-joints-regeneration-breakthrough/
Human limbs soon? Scientists regrow mice
toes in major regenerative breakthrough
Researchers have concluded a “transformational” study in which,
for the first time, they have successfully regenerated joint as
well as bone tissue in amputated mice, a step which holds great
promise for human limb regeneration.
Scientists at Texas A&M University were able to artificially
stimulate growth in damaged or amputated limbs of neonatal mice,
using just two proteins: BMP2 and BMP9.
“These studies provide evidence that treatment of growth factors
can be used to engineer a regeneration response from a
non-regenerating amputation wound,”explain the researchers in
their paper.
Their new research indicates joint regrowth, a level of complexity
hitherto unforeseen, which provides a critical step towards one
day replacing human limbs. The scientists were attempting to
recreate behavior typically displayed by reptilian cells in
mammalian cells.
Cancer-fighting nanomeds can do more harm than good, new research
says Cancer-fighting nanomeds can do more harm than good, new
research says
“Our study is transformational,” Ken Muneoka from Texas A&M
University, told New Scientist. “They can do it, they just don't
do it,” he adds. “So, we have to figure out what's constraining
them."
Bone regrowth has been achieved before, but without the additional
protein, the bones would just heal over as normal rather than
growing joint and cartilage tissue. Over 60 percent of the mice’s
bone stumps formed a layer of cartilage within three days.
While admittedly just a small step, the research could ultimately
provide breakthroughs in treatments for disorders like
osteoarthritis as it would allow for replacement of cartilage from
a person’s own cells rather than relying on transplants.
“These findings provide further support for the view that cells of
a non-regenerative mammalian amputation wound retain the
positional information necessary to re-build structures removed by
amputation,” the researchers concluded.
https://www.nature.com/articles/s41467-018-08278-4
Nature Communicationsvolume 10, Article number: 424
(2019)
BMP9 stimulates joint regeneration at digit
amputation wounds in mice
Ling Yu, Lindsay A. Dawson, Mingquan Yan, Katherine Zimmel,
Yu-Lieh Lin, Connor P. Dolan, Manjong Han & Ken Muneoka
Abstract
A major goal of regenerative medicine is to stimulate tissue
regeneration after traumatic injury. We previously discovered that
treating digit amputation wounds with BMP2 in neonatal mice
stimulates endochondral ossification to regenerate the stump bone.
Here we show that treating the amputation wound with BMP9
stimulates regeneration of a synovial joint that forms an
articulation with the stump bone. Regenerated structures include a
skeletal element lined with articular cartilage and a synovial
cavity, and we demonstrate that this response requires the Prg4
gene. Combining BMP2 and BMP9 treatments in sequence stimulates
the regeneration of bone and joint. These studies provide evidence
that treatment of growth factors can be used to engineer a
regeneration response from a non-regenerating amputation wound...
Run away already !!!
https://www.youtube.com/watch?v=Ycwe5oV0hHE
Clif High, Episode 1, DIY Jedi training.
Preparing for BugWar
https://www.youtube.com/watch?v=wOE4UegzJ_M
How to Cure our Concrete Dependency
https://www.youtube.com/watch?v=uGZrUASys6Q
The Culling of the UK Population!
by Ian R Crane (2018)
https://www.youtube.com/watch?v=bwDbwaV_mPQ
Ice Man of Ladakh: Chewang Norphel who
builds artificial glaciers
"Christic" S&M = Love :
https://www.youtube.com/watch?v=V4nCaxHN-cY
Penn And Teller BS : Christopher Hitchens
on Mother Teresa
https://www.sciencedaily.com/releases/2019/01/190130133209.htm
Layered cocktails inspire new form of male
birth control
For decades, women have shouldered most of the burden of
contraception. However, long-term use of female birth control
pills could increase the risk for side effects such as blood clots
or breast cancer. Now, inspired by colorful layered cocktails,
researchers have developed a medium-term, reversible male
contraceptive. They report their results in the journal ACS Nano.
Common forms of male contraception are either short-term (condoms)
or long-term (vasectomy). However, condoms can fail, and
vasectomies, while effective, are not often reversible. Xiaolei
Wang and colleagues wanted to devise a medium-term, reversible
form of male contraception. They drew inspiration from cocktails,
such as the Galaxy, that bartenders make by layering colorful
liquids in a glass. If the beverage is stirred or heated, the
layers combine into a uniform liquid. Wang and colleagues wondered
if they could use a similar approach to inject layers of materials
to block the vas deferens, the duct that conveys sperm from the
testicle to the urethra. Applying heat would cause the layers to
mix, breaking them down and "unplugging the pipeline."
The team tested their approach in male rats. They sequentially
injected four layers of materials into the vas deferens: a
hydrogel that forms a physical barrier to sperm; gold
nanoparticles, which heat up when irradiated with near-infrared
light; ethylenediaminetetraacetic acid (EDTA), a chemical that
breaks down the hydrogel and also kills sperm; and finally,
another layer of gold nanoparticles. The injected materials kept
the rats from impregnating females for more than 2 months.
However, when the researchers shone a near-infrared lamp on the
rats for a few minutes, the layers mixed and dissolved, allowing
the animals to produce offspring. The researchers say that while
this pilot experiment is promising, more research is needed to
verify the safety of the materials.
ACS Nano, 2019; DOI: 10.1021/acsnano.8b06683
A Cocktail-Inspired Male Birth Control
Strategy with Physical/Chemical Dual Contraceptive Effects and
Remote Self-Cleared Properties.
Weiwei Bao, et al.
Olga Malinkiewicz, et al.: Perovskite Film
https://www.afp.com/en/news/826/inkjet-solar-panels-poised-revolutionise-green-energy-doc-1cu3051
'Inkjet' solar panels poised to
revolutionise green energy
hat if one day all buildings could be equipped with windows and
facades that satisfy the structure's every energy need, whether
rain or shine?
That sustainability dream is today one step closer to becoming a
reality thanks to Polish physicist and businesswoman Olga
Malinkiewicz.
The 36-year-old has developed a novel inkjet processing method for
perovskites -- a new generation of cheaper solar cells -- that
makes it possible to produce solar panels under lower
temperatures, thus sharply reducing costs.
Indeed, perovskite technology is on track to revolutionise access
to solar power for all, given its surprising physical properties,
some experts say.
"In our opinion, perovskite solar cells have the potential to
address the world energy poverty," said Mohammad Khaja
Nazeeruddin, a professor at Switzerland's Federal Institue of
Technology Lausanne, an institution on the cutting-edge of solar
energy research.
Solar panels coated with the mineral are light, flexible,
efficient, inexpensive and come in varying hues and degrees of
transparency.
They can easily be fixed to almost any surface -- be it laptop,
car, drone, spacecraft or building -- to produce electricity,
including in the shade or indoors.
Though the excitement is new, perovskite has been known to science
since at least the 1830s, when it was first identified by German
mineralogist Gustav Rose while prospecting in the Ural mountains
and named after Russian mineralogist Lev Perovski.
In the following decades, synthesising the atomic structure of
perovskite became easier.
But it was not until 2009 that Japanese researcher Tsutomu
Miyasaka discovered that perovskites can be used to form
photovoltaic solar cells.
- 'Bull's eye' -
Initially the process was complicated and required ultra high
temperatures, so only materials that could withstand extreme heat
-- like glass -- could be coated with perovskite cells.
This is where Malinkiewicz comes in.
In 2013, while still a PhD student at the University of Valencia
in Spain, she figured out a way to coat flexible foil with
perovskites using an evaporation method.
Later, she developed an inkjet printing procedure that lowered
production costs enough to make mass production economically
feasible.
"That was a bull's eye. Now high temperatures are no longer
required to coat things with a photovoltaic layer," Malinkiewicz
told AFP. They panels can easily be fixed to almost any surface
Her discovery quickly earned her an article in the journal Nature
and media attention, as well as the Photonics21 Student Innovation
award in a competition organised by the European Commission.
The Polish edition of the MIT Technology Review also selected her
as one of its Innovators Under 35 in 2015.
She went on to cofound the company Saule Technologies -- named
after the Baltic goddess of the sun -- along with two Polish
businessmen.
They had to assemble all their laboratory equipment from scratch,
before multimillionaire Japanese investor Hideo Sawada came on
board.
The company now has an ultra-modern laboratory with an
international team of young experts and is building an
industrial-scale production site.
"This will be the world's first production line using this
technology. Its capacity will reach 40,000 square metres of panels
by the end of the year and 180,000 square metres the following
year," Malinkiewicz said at her lab.
"But that's just a drop in the bucket in terms of demand."
Eventually, compact production lines could easily be installed
everywhere, according to demand, to manufacture perovskite solar
panels that are made to measure.
- Self-sufficient buildings -
The Swedish construction group Skanska is testing the cutting-edge
panels on the facade of one of its buildings in Warsaw.
It also inked a licencing partnership with Saule in December for
the exclusive right to incorporate the company's solar cell
technology in its projects in Europe, the United States and
Canada.
"Perovskite technology is bringing us closer to the goal of energy
self-sufficient buildings," said Adam Targowski, sustainability
manager at Skanska.
"Perovskites have proven successful even on surfaces that receive
little sunlight. We can apply them pretty much everywhere," he
told AFP.
"More or less transparent, the panels also respond to design
requirements. Thanks to their flexibility and varying tints,
there's no need to add any extra architectural elements."
A standard panel of around 1.3 square metres, at a projected cost
of 50 euros ($57), would supply a day's worth of energy to an
office workstation, according to current estimates.
Malinkiewicz insists that the initial cost of her products will be
comparable to conventional solar panels.
Perovskite technology is also being tested on a hotel in Japan,
near the city of Nagasaki.
Plans are also afoot for the pilot production of perovskite panels
in Valais, Switzerland and in Germany under the wings of the
Oxford Photovoltaics venture.
"The potential of the technology is clearly enormous," Assaad
Razzouk, the CEO of Singapore-based Sindicatum Rewable Energy, a
developer and operator of clean energy projects in Asia, told AFP.
"Just think of all the buildings one could retrofit worldwide!"
Optoelectronic film and method for producing optoelectronic
film
PL420300
Inverted solar cell and process for producing the same
CN105900255
A FILM-FORMING COMPOSTION AND A METHOD FOR MANUFACTURNIG A
PHOTOACTIVE FILM
EP3227394
http://www.vrijewereld.org/pdf-bibliotheek/
Scads of PDF books re:
suppression/conspiracy &c...
https://www.voltairenet.org/IMG/pdf/Sutton_Wall_Street_and_Hitler-4.pdf
Wall Street and the Rise of Hitler
by Anthony Sutton
http://reciprocalsystem.org/PDFa/The%20Simple%20Essence%20of%20Dewey%20B.%20Larson%27s%20Reciprocal%20System%20of%20Physics%20(Boardman,%20Jameela).pdf
J. M. Boardman – The Simple Essence of
Dewey B. Larson’s Reciprocal System of Physics
https://www.youtube.com/watch?v=-Mxk3G6lqq4
Prophesies by St. Kosmas Aitolos
Father Kosmas Aitolos was born in 1714 in the Greek village Megalo
Dendro (Big Tree) in the region of Aitolia. He studied in Mount
Athos, in “Athonias School”, and later he became a monk in
Philotheou Monastery. Because of the lack of education in
most of the population, especially in the remote areas of Greece,
Father Kosmas was “forced” to live Athos and begin missionary
tours in the villages with the aim of educating the poor people.
This way he would also be able to help people understand the
Scriptures better. In a period of six years he managed to
establish 250 schools as well as charities and rural churches.
On August 24, 1779 he was executed at Kolkondas, Fier District,
near the mouth of the Seman river (in present day Albania) by the
Ottoman authorities. There were no formal charges against him.
He was recognized as a saint by the Patriarchate of Constantinople
Athenagoras in 1961.
St. Kosmas received from God the gift of prophecy. He seems to
have foreseen everything. He predicted the future of the world, he
warned of the great cataclysms which await us in our Apocalyptic
times but also he foretold the new technological developments.
Some of them became reality and others are about to be fulfilled.
In the following quotes several of his prophecies are presented.
PROPHECIES AND SAYINGS
You will see people flying in the sky like blackbirds and hurling
fire on the earth. Those alive then will run to the graves and
shout: “Come out, you who are dead, and let us who are living in.”
The cause of the general war will come from Dalmatia. Austria will
be dismembered first and then Turkey.
That which is desired [i.e., freedom] will come in the third
generation. Your grandchildren will see it.
France will liberate Greece, [while] Italy (will liberate) Epiros.
The villages of the plain will suffer destruction, while people at
the foot of (Mount) Kissavo will go to sleep slaves and will
awaken free.
The time will come when your enemies will take away from you even
the ashes from your fires, but don’t give up your faith as others
will do.
The red hats [ie., the French] will come here [Kephallenia], and
then the English for fifty-four years, and then this place will
become Roman [i.e., Greek Orthodox].
The time will come when people will speak from one far place to
another, for example, from Constantinople to Russia, as though
they were in adjoining rooms.
A time will come when the harmony that exists now between clergy
and laymen will not be.
The time will come when the devil will make his turns with his
pumpkin.
They will put a tax on chickens and on windows.
Clergymen will become worse and more impious than everyone.
There will come a time when your enemies will even take away from
you the ashes from your fire, but do not deny your faith, as
others may do.
People will become impoverished because they will have no love for
trees.
You will see in the plain a carriage without horses which will run
faster than a rabbit.
The rich will become poor and the poor will die.
The time will come when the Romans [i.e., the Greek Orthodox] will
fight among themselves. I recommend harmony and love.
A foreign army will come. It will believe in Christ, but it will
not speak the (Greek) language.
After the general war, the wolf will live with the lamb.
People will become poor because they will become lazy.
They will seek to take you as soldiers, but they will not do so in
time.
The Turks will learn the secret three days sooner than the
Christians.
When you hear that the war has started from below (the south),
then it will be near.
If the war starts from below (the south), you will suffer little.
If it starts from above (the north), you will be destroyed.
The crags and the pits will be full of people.
It will come quickly. And either the ox will be in the field or
the horse on the threshing floor.
It is sad for me to say it to you: today, tomorrow we will endure
thirst and great hunger such that we would give thousands of gold
coins but still will not find a little bread.
After the war, a man will have to run half an hour to find another
human being to join him in fellowship.
They will ask for your rifles. Retain two. Give one and keep the
other. A single rifle will save a hundred souls.
Out of schools will come things which your mind can’t imagine.
Have a cross on your forehead so that they know that you are
Christian.
There will come a time when your enemies will even take away from
you the ashes from your fire, but do not deny your faith, as
others may do.
http://www.guaduabamboo.com/making-bamboo-cables.html
http://greaterancestors.com/bamboo-cable-steel/
Bamboo cable, comparable to steel in
tensile strength was being used at minimum 2000 years ago.
Marco Polo described how the Chinese used and manufactured
bamboo cables for towing boats.
Engineers experimenting for the Whangpoo Conservancy Board found
out that these twisted and plaited bamboo cables were made with
material taken from the outer layer of the bamboo (which was only
1/8 inch or 3 mm thick). They estimated that the working stress
was about 20,000 pounds per square inch, which was of the same
order as normally taken by steel wires of the same size.
The breakages were very few with bamboo cables. Moreover, while
hempen ropes lose some 25 percent of their strength when wet, the
tensile strength of plaited bamboo cables increases about 20
percent when they are fully saturated with water. Bamboo cables
were available in lengths up to a quarter mile.
Bamboo cables were the earliest structural element in the history
of engineering to be used for suspension bridges, which originated
in western China and the Himalayas.
Primitive bridges made of bamboo cables droop across gorges with
one end fixed lower than the other. Bamboo tubes greased with yak
butter slide down the cables, with a cradle hanging from them in
which people and animals side. Of great strength, a bamboo cable
of 2 inch diameter could support 4 ton, these ancient bridges
spanned distances up to 76 meters without central supports.
Later on, various designs combined whole bamboo culms, woven
slats, and cables braided of workable species such as Gigantochloa
apus, which was a favorite for bridges in Java.
The Anlan Bridge
The remarkable Anlan bridge on the Min River in China was first
constructed around 300 AD. Historians consider this bridge one of
the engineering marvels of the ancient world.
Bamboo cables have a tensile strength of up to 26,000 pounds per
square inch, while hemp rope can only carry a stress of 8,000
pounds.
The Anlan suspension bridge spans the 1,000-foot wide Min River,
is 9 feet wide, and was built entirely of bamboo cables resting on
seven supports fixed equidistant in the bed of the stream. The
floor of the bridge rested across 10 bamboo cables, each 21 inches
in circumference, and five similar cables on each side form the
rails.
Moreover, the silica-containing outer surface is very resistant to
wear, e.g., against rock surfaces, which is naturally important
both in towing and bridge cables.
Some Related Patents:
METHOD FOR MANUFACTURING COMPRESSED AND HARDENED BODY OF
BAMBOO FIBRES, AND COMPRESSED AND HARDENED BODY OF BAMBOO FIBRES
MANUFACTURED BY SAID METHOD
WO2017204360
Bamboo fiber production technology
CN105734743
GB296333
Processes for the treatment of plant materials in the
preparation of fibres
CN106584629
Manufacture process for recombined bamboo
https://www.capitolhilloutsider.com/islams-conquest-of-america-through-creeping-sharia/
Islam’s Conquest of America Through
Creeping Sharia
By Kelleigh Nelson
Keith Clark : I recorded one full year of tones. It is all
documented, here is a sample of me being sent tones....it turned
out to be music.... My work is centered around life after
death.... with a specialty in radio. I
use live noise reduction/filtering and stream it back to the
internet live. Over 13 years I've recorded many amazing things (in
static), actually it's
a joint effort between myself and whomever the communicators are.
I try to build up energy and speak to them... To keep it short, I
believe I have received both tones and guttural voices.
https://www.youtube.com/playlist?list=PLLB-82YMhiPEC2lKS8kGFvmy_1Kowazj3
https://idigitalmedium.com/
iDigitalMedium Team (Keith Clatk, et al. )
A NONPROFIT ORGANIZATION FOR RESEARCH, EDUCATION, AND
PRESERVATION OF DATA REGARDING LIFE AFTER DEATH AND BEYOND
Instrumental Transcommunication
http://www.worldwatch.org/node/4803
New Solar Cell "Most Efficient Ever"
Scientists have created a solar cell device that is significantly
more efficient than conventional photovoltaic cells.
For the first time, scientists have produced a photovoltaic (PV)
cell with a conversion efficiency of 40.7 percent, the U.S.
Department of Energy (DOE) reported on December 7. The
collaboration of DOE and Spectrolab, Inc. (a subsidiary of Boeing)
led to the achievement of a decades-long goal: to break the
40-percent efficiency barrier on solar cell devices. “We are eager
to see this accomplishment translate into the marketplace as soon
as possible,” Alexander Karsner, assistant secretary for energy
efficiency and renewable energy at DOE, said.
The breakthrough cell was developed using a structure called a
“multi-junction solar cell.” In this type of device, individual PV
cells are made of layers, and each layer captures a portion of the
sunlight reaching the cell. This allows the unit to capture energy
from a greater range of the solar spectrum, leading to higher
efficiency. According to Dr. Richard King, a principal
investigator at Spectrolab, “The excellent performance of these
materials hints at still higher efficiency in future solar cells.”
According to Spectrolab, the highly efficient units allow for the
use of fewer cells overall to achieve the same power output as
conventional silicon cells. As a result, the technology may allow
for lower PV system installation costs, at $3 per watt, and
electricity production costs of $0.08–$0.10 cents per
kilowatt-hour. The acheivement has the greater potential of
helping to reduce the U.S. reliance on imported oil and increase
national energy security, DOE’s Karsner notes.
https://www.theepochtimes.com/huge-barrier-isnt-trapping-plastic-waste-in-pacific-ocean_2742281.html
Huge Barrier Isn’t Trapping Plastic Waste
in Pacific Ocean
LOS ANGELES—A floating device sent to corral a swirling island of
trash between California and Hawaii has not swept up any plastic
waste—but the young innovator behind the project said on Dec. 17,
that a fix was in the works.
Boyan Slat, 24, who launched the Pacific Ocean cleanup project,
said the speed of the solar-powered barrier isn’t allowing it to
hold on to the plastic it catches.
“Sometimes the system actually moves slightly slower than the
plastic, which of course you don’t want because then you have a
chance of losing t
he plastic again,” Slat said in an interview with The Associated
Press.
A crew of engineers will reach the U-shaped boom on Dec. 18, and
will work for the next few weeks to widen its span so that it
catches more wind and waves to help it go faster, he said.
A ship towed the 2,000-foot barrier in September from San
Francisco to the Great Pacific Garbage Patch—an island of trash
twice the size of Texas. It has been in place since the end of
October, Slat said.
The plastic barrier with a tapered 10-foot-deep screen is intended
to act like a coastline, trapping some of the 1.8 trillion pieces
of plastic that scientists estimate are swirling in the patch
while allowing marine life to safely swim beneath it.
So far the giant floating device, launched three months ago to
collect plastic in the Pacific garbage patch has not been
successful. But the Ocean Cleanup’s founder said, with changes,
he’s confident it’ll still work.
Slat said he is not deterred by the setback because engineers
expected to make tweaks to the system...
https://www.theepochtimes.com/study-finds-clear-evidence-linking-cellphone-radiation-to-tumors-in-rats_2709524.html
Study Finds ‘Clear Evidence’ Linking
Cellphone Radiation to Tumors in Rats
By Holly Kellum
https://www.youtube.com/watch?v=GD30QvUJfXQ
Causes of the Ice Ages, Part 4A; the 14C
Evidence of the 12,068 year Clock Cycle.
http://avalonlibrary.net/ebooks/Joseph%20P.%20Farrell%20-%20Covert%20Wars%20and%20Breakaway%20Civilizations%20-%20The%20Secret%20Space%20Program,%20Celestial%20Psyops%20and%20Hidden%20Conflicts.pdf
Covert Wars & Breakaway Civilizations
Dr Jos. Farrell
http://www.mediafire.com/file/xfshct650g6b7wu/367844333333.pdf
The Source Field Investigations
by David Wilcock
http://concerneduspatriots.com/fema-director-calls-citizens-cattle/
FEMA DIRECTOR CALLS CITIZENS “CATTLE”
During a government shutdown that furloughed hundreds of thousands
of workers, the Federal Emergency Management Agency (FEMA)
continued operating and quietly received a $400,000,000 budget
increase to further its insidious agenda to enslave or eradicate a
majority of the population. At an agency meeting last Tuesday,
FEMA Director Brock Long told regional subordinates that citizens
who question the agency’s mission are “nothing more than cattle”
and must be treated as hostile combatants.
He cited a recent disturbance in fire-stricken Paradise, CA; local
subversives, he said, protested FEMA’s presence by forming a human
blockade to prevent agents from unlawfully trespassing on private
property or entering the charred remains of scorched homes and
businesses. A group of approximately twenty-five persons held
protest signs reading “FEMA, WE DON’T WANT YOU HERE” and “FEMA, GO
HOME.”
Long told colleagues that agents must not hesitate to use
discreet, lethal force if citizens defy FEMA’s authority, and
reminded them that powers granted by the Patriot Act absolve
agents of criminal maleficence when acting in the line of
duty. He warned them, however, not to shoot anybody in the
presence of media personalities.
Our FEMA source said the following: “Brock Long continues to
perceive everyday people as a threat to his authority. And what
happened in California has strengthened his paranoia. He wants the
population subservient to FEMA. To him, you’re all livestock ready
for the slaughterhouse. We’re talking about a man who has ordered
agents to toss people off boats. Even supervisors who
disagree with his policies are powerless to stop him.”..
https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12597
https://doi.org/10.1111/jsr.12597
Self-administered acupressure for insomnia
disorder: a pilot randomized controlled trial
Wing-Fai Yeung, et al.
https://science.news/2018-12-04-south-african-plant-displays-impressive-anti-diabetic-profile.html
South African plant displays impressive
anti-diabetic profile
A South African study, which was published in the journal
Pharmacognosy Research, discovered that the bushy bulbine (Bulbine
abyssinica) is rich in polyphenols that contribute to its
antidiabetic and antioxidant activities. This finding was based on
the results of different in vitro studies....
http://www.phcogres.com/article.asp?issn=0974-8490;year=2018;volume=10;issue=1;spage=72;epage=80;aulast=Odeyemi
DOI: 10.4103/pr.pr_55_17
Identification of Antidiabetic Compounds
from Polyphenolic-rich Fractions of Bulbine abyssinica A. Rich
Leaves
Samuel Wale Odeyemi, Anthony Jide Afolayan
Abstract
Background: Bulbine abyssinica has been reported to possess a
variety of pharmacological activities traditionally. Previous work
suggested its antidiabetic properties, but information on the
antidiabetic compounds is still lacking. Objective: The present
research exertion was aimed to isolate and identify biologically
active polyphenols from B. abyssinica leaves and to evaluate their
efficacy on carbohydrate digesting enzymes. Materials and Methods:
Fractionation of the polyphenolic contents from the methanolic
extract of B. abyssinica leaves was executed by the silica gel
column chromatography to yield different fractions. The
antioxidant activities of these fractions were carried out against
2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) diammonium
salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl radicals, and ferric
ion-reducing antioxidant power (FRAP). In vitro antidiabetic
experimentation was performed by evaluating the a-amylase and
a-glucosidase inhibitory capacity. The isolated polyphenols were
then identified using liquid chromatography and mass spectroscopy
(LC/MS). Results: Out of the eight polyphenolic fractions (BAL
1–8), BAL-4 has the highest inhibitory activity against ABTS
radicals whereas BAL-6 showed potent ferric ion-reducing capacity.
BAL-5 was the most effective fraction with antidiabetic activity
with IC50of 140.0 and 68.58 ± 3.2 µg/ml for a-amylase and
a-glucosidase inhibitory activities, respectively. All the
fractions competitively inhibited a-amylase, BAL-5 and BAL-6 also
inhibited a-glucosidase competitively, while BAL-4 and BAL-1
exhibited noncompetitive and near competitive inhibitions against
a-glucosidase, respectively. The LC/MS analysis revealed the
presence of carvone in all the fractions. Conclusions: The present
study demonstrates the antioxidant and antidiabetic activities of
the isolated polyphenols from B. abyssinica.
Summary
Polyphenols were successfully isolated and identified from Bulbine
abyssinica leaves
The isolated polyphenols are biologically active with high
antioxidant as well as inhibitor of carbohydrate-digesting enzymes
B. abyssinica can be a good source of amylase and glucosidase
inhibitors
B. abyssinica can be used as complementary or alternative
therapeutic agents especially for the treatment of diabetes
Carvone, quercetin, and psoralen could be the compounds
responsible for the a-amylase and a-glucosidase inhibitory
activities.
Introduction
Plants produce a variety of secondary products having one or more
hydroxyl functional groups on an aromatic ring called phenol.[1]
These plant phenolics play important role in the plant defense
mechanism against diseases and pests.[2] Phenolic acids can be
classified into derivatives of benzoic acid and caffeic acid.
Example of the benzoic derivative is the gallic acid while
examples of the caffeic acid are coumaric and ferulic acids.[3]
However, flavonoids, flavonols, tannins, lignins, and stilbenes
are examples of plant phenolics. Plant phenolics have been used as
food additives due to their distinctive odor and as ingredients in
perfume. Recently, much attention has been focused on the potent
antioxidative properties of polyphenolics and conversely their
effects in the prevention of various oxidative stress-associated
diseases. Free radicals are produced during oxidation processes
and have been implicated in the cause of many human diseases such
as cancer, diabetes, atherosclerosis, inflammation, cardiac,
Alzheimer's, kidney, liver diseases, and aging.[3],[4],[5] The
prevention of oxidative stress by plant polyphenols and their use
in treatment of diseases is of increasing importance from the
epidemiological data as well as in vitro and in vivo studies.[6]
Asteraceae have been reported to be the largest family of
flowering plants with many of its members shown to have
pharmacological activities which contained important
phytochemicals including polyphenolics and
diterpenoids.[7],[8]Bulbine abyssinica A. rich belongs to this
family and has been previously described to be rich in
polyphenolics.[9] Further studies on the acetone and water
extracts from the whole plant evaluated in vitro assays showed
antioxidant potential, hypoglycemic, and advanced glycation
end-products inhibition capacity.[9] In this study, antioxidant
and antidiabetic properties of different polyphenol fractions were
investigated through bioassay-guided isolation from the leaves of
B. abyssinica...
Preparation of plant extracts and fractionation
The dried B. abyssinica leaves were washed, dried, and finely
chopped using a grinder and then about 1 kg was macerated with
methanol for 5 days and the extract evaporated under reduced
pressure at 40°C, affording 200 g of the crude extract. This was
then loaded into a glass column containing silica gel 60
(0.063–0.200 nm) that has been previously washed with methanol and
then eluted with methanol/ethyl acetate (2:8), ethyl
acetate/hexane (7:3), methanol/ethyl acetate (8:2), and methanol
to yield 8 fractions (BAL-1 to BAL-8). The elutions were examined
by thin-layer chromatography and each one of them was dried,
weighed, and reconstituted with methanol to prepare a stock
solution at concentration of 1 mg/ml for preliminary screening of
total phenolic contents, flavonoids, proanthocyanidins,
2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and
DPPH scavenging activity. The fractions having the best
polyphenolic contents and antioxidant activity were selected for
further experiments; these fractions are BAL-4, BAL-6, BAL-5,
BAL-8, BAL-7, and BAL-1 in the order of their activity...
Conclusions
Based on the results of this study, it can be concluded that
the polyphenolics isolated from B. abyssinica have significant
antioxidant activities and inhibitory properties against a-amylase
and a-glucosidase enzymes. The antidiabetic activities could be as
a result of the carvone, quercetin, and psoralen contents of the
plant. Therefore, B. abyssinica is an easily accessible source of
natural antioxidants and antidiabetic compounds. This also
confirms the folkloric usage of the plant for the treatment of
diabetes. However, further studies need to be carried out on the
isolation, purification, and elucidation of the structural
properties of these compounds.
https://www.sciencedaily.com/releases/2018/12/181231103951.htm
The immune system's fountain of youth
Helping the immune system clear away old cells in aging mice
helped restore youthful characteristics
If only we could keep our bodies young, healthy and energetic,
even as we attain the wisdom of our years. New research at the
Weizmann Institute of Science suggests this dream could be at
least partly obtainable in the future. The results of this
research, led by Prof. Valery Krizhanovsky and Dr. Yossi Ovadya in
the Molecular Cell Biology Department, were recently published in
Nature Communications.
The research began with an investigation into the way that the
immune system is involved in a crucial activity: clearing away
old, senescent cells that spell trouble for the body when they
hang around. Senescent cells -- not completely dead but suffering
loss of function or irreparable damage -- have been implicated in
diseases of aging by promoting inflammation. The researchers used
mice in which a crucial gene for this immune activity was missing.
At two years (elderly, for mice), the bodies of these mice had a
greater accumulation of senescent cells compared with the mice in
which the gene for removing these cells was intact. The mice
missing the gene suffered from chronic inflammation, and various
functions in their bodies appeared to be diminished. They also
looked older -- and died earlier -- than their normal
counterparts.
Next, the researchers gave the mice a drug that inhibits the
function of certain proteins that help the aging cells survive in
their senescent state, to see if this would contribute to the
removal of these cells from the body. The drugs were administered
to mice whose aging was a result of the malfunctions the group had
uncovered in the immune system as well as those suffering
premature aging from a different genetic error. The treated mice
responded exceptionally well to the drug: Their blood tests and
activity tests showed improvement, and their tissues appeared to
be much closer to those of young mice. The scientists counted
senescent cells, finding many fewer of them remaining in the
treated mice's bodies; and when they looked for signs of
inflammation, they found that this, too, was significantly lower.
The mice treated with the drug were more active and their median
lifespan rose....
The scientists intend to continue exploring ways to prompt the
human body to remove its old senescent cells, particularly to find
means of activating the immune system to do this job. That is, if
future experimentation proves their theories correct, they could
end up creating truly "anti-aging" therapies.
Nature Communications, 2018; 9 (1)
DOI: 10.1038/s41467-018-07825-3
Impaired immune surveillance accelerates
accumulation of senescent cells and aging.
Yossi Ovadya, et al.
https://b-ok.cc/book/498613/369b78
History of Wireless
T. K. Sarkar, Robert Mailloux, Arthur A. Oliner, M.
Salazar-Palma, Dipak L. Sengupta
Premised on the idea that one cannot know a science without
knowing its history, History of Wireless offers a lively new
treatment that introduces previously unacknowledged pioneers and
developments, setting a new standard for understanding the
evolution of this important technology.Starting with the
background-magnetism, electricity, light, and Maxwell's
Electromagnetic Theory-this book offers new insights into the
initial theory and experimental exploration of wireless. In
addition to the well-known contributions of Maxwell, Hertz, and
Marconi, it examines work done by Heaviside, Tesla, and passionate
amateurs such as the Kentucky melon farmer Nathan Stubblefield and
the unsung hero Antonio Meucci. Looking at the story from
mathematical, physics, technical, and other perspectives, the
clearly written text describes the development of wireless within
a vivid scientific milieu.
https://b-ok.cc/book/489790/eea343
Science and Technology in World History
James E. McClellan, Harold Dorn
Now in its second edition, this bestselling textbook may be the
single most influential study of the historical relationship
between science and technology ever published. Tracing this
relationship from the dawn of civilization through the twentieth
century, James E. McClellan III and Harold Dorn argue that
technology as "applied science" emerged relatively recently, as
industry and governments began funding scientific research that
would lead directly to new or improved technologies. McClellan and
Dorn identify two great scientific traditions: the useful
sciences, patronized by the state from the dawn of civilization,
and scientific theorizing, initiated by the ancient Greeks. They
find that scientific traditions took root in China, India, and
Central and South America, as well as in a series of Near Eastern
empires, during late antiquity and the Middle Ages. From this
comparative perspective, the authors explore the emergence of
Europe and the United States as a scientific and technological
power.The new edition reorganizes its treatment of Greek science
and significantly expands its coverage of industrial civilization
and contemporary science and technology with new and revised
chapters devoted to applied science, the sociology and economics
of science, globalization, and the technological systems that
underpin everyday life.
https://b-ok.cc/book/550995/c31ec1
Technology - A World History
Daniel R. Headrick
Today technology has created a world of dazzling progress, growing
disparities of wealth and poverty, and looming threats to the
environment. Technology: A World History offers an illuminating
backdrop to our present moment--a brilliant history of invention
around the globe. Historian Daniel R. Headrick ranges from the
Stone Age and the beginnings of agriculture to the Industrial
Revolution and the electronic revolution of the recent past. In
tracing the growing power of humans over nature through
increasingly powerful innovations, he compares the evolution of
technology in different parts of the world, providing a much
broader account than is found in other histories of technology. We
also discover how small changes sometimes have dramatic
results--how, for instance, the stirrup revolutionized war and
gave the Mongols a deadly advantage over the Chinese. And how the
nailed horseshoe was a pivotal breakthrough for western farmers.
Enlivened with many illustrations, Technology offers a fascinating
look at the spread of inventions around the world, both as boons
for humanity and as weapons of destruction.
https://b-ok.cc/book/553897/acc8d1
A History of the Theories of Aether and
Electricity -From The Age of Descart
Edmund T Whittaker
https://www.americanthinker.com/articles/2018/01/what_i_learned_in_peace_corps_in_africa_trump_is_right.html
What I Learned in the Peace Corps in
Africa: Trump Is Right
By Karin McQuillan
Three weeks after college, I flew to Senegal, West Africa, to run
a community center in a rural town. Life was placid, with no
danger, except to your health. That danger was considerable,
because it was, in the words of the Peace Corps doctor, "a
fecalized environment."
In plain English: s--- is everywhere. People defecate on the
open ground, and the feces is blown with the dust – onto you, your
clothes, your food, the water. He warned us the first day of
training: do not even touch water. Human feces carries
parasites that bore through your skin and cause organ failure.
Never in my wildest dreams would I have imagined that a few
decades later, liberals would be pushing the lie that Western
civilization is no better than a third-world country. Or
would teach two generations of our kids that loving your own
culture and wanting to preserve it are racism.
Last time I was in Paris, I saw a beautiful African woman in a
grand boubou have her child defecate on the sidewalk next to Notre
Dame Cathedral. The French police officer, ten steps from
her, turned his head not to see.
I have seen. I am not turning my head and pretending
unpleasant things are not true.
Senegal was not a hellhole. Very poor people can lead happy,
meaningful lives in their own cultures' terms. But they are
not our terms. The excrement is the least of it. Our
basic ideas of human relations, right and wrong, are incompatible.
As a twenty-one-year-old starting out in the Peace Corps, I loved
Senegal. In fact, I was euphoric. I quickly made
friends and had an adopted family. I relished the feeling of
the brotherhood of man. People were open, willing to share
their lives and, after they knew you, their innermost thoughts.
The longer I lived there, the more I understood: it became
blindingly obvious that the Senegalese are not the same as
us. The truths we hold to be self-evident are not evident to
the Senegalese. How could they be? Their reality is
totally different. You can't understand anything in Senegal
using American terms.
Take something as basic as family. Family was a few hundred
people, extending out to second and third cousins. All the
men in one generation were called "father." Senegalese are
Muslim, with up to four wives. Girls had their clitorises
cut off at puberty. (I witnessed this, at what I thought was
going to be a nice coming-of-age ceremony, like a bat mitzvah or
confirmation.) Sex, I was told, did not include
kissing. Love and friendship in marriage were Western
ideas. Fidelity was not a thing. Married women would
have sex for a few cents to have cash for the market.
What I did witness every day was that women were worked half to
death. Wives raised the food and fed their own children, did
the heavy labor of walking miles to gather wood for the fire, drew
water from the well or public faucet, pounded grain with heavy
hand-held pestles, lived in their own huts, and had conjugal
visits from their husbands on a rotating basis with their
co-wives. Their husbands lazed in the shade of the trees.
Yet family was crucial to people there in a way Americans cannot
comprehend.
The Ten Commandments were not disobeyed – they were unknown.
The value system was the exact opposite. You were supposed
to steal everything you can to give to your own relatives.
There are some Westernized Africans who try to rebel against the
system. They fail.
We hear a lot about the kleptocratic elites of Africa. The
kleptocracy extends through the whole society. My town had a
medical clinic donated by international agencies. The
medicine was stolen by the medical workers and sold to the local
store. If you were sick and didn't have money, drop
dead. That was normal.
So here in the States, when we discovered that my 98-year-old
father's Muslim health aide from Nigeria had stolen his clothes
and wasn't bathing him, I wasn't surprised. It was familiar.
Go to the post office, and the clerk would name an outrageous
price for a stamp. After paying the bribe, you still didn't
know it if it would be mailed or thrown out. That was
normal.
One of my most vivid memories was from the clinic. One day,
as the wait grew hotter in the 110-degree heat, an old woman two
feet from the medical aides – who were chatting in the shade of a
mango tree instead of working – collapsed to the ground.
They turned their heads so as not to see her and kept
talking. She lay there in the dirt. Callousness to the
sick was normal.
Americans think it is a universal human instinct to do unto others
as you would have them do unto you. It's not. It seems
natural to us because we live in a Bible-based Judeo-Christian
culture.
We think the Protestant work ethic is universal. It's
not. My town was full of young men doing nothing. They
were waiting for a government job. There was no private
enterprise. Private business was not illegal, just
impossible, given the nightmare of a third-world bureaucratic
kleptocracy. It is also incompatible with Senegalese
insistence on taking care of relatives.
All the little stores in Senegal were owned by Mauritanians.
If a Senegalese wanted to run a little store, he'd go to another
country. The reason? Your friends and relatives would
ask you for stuff for free, and you would have to say yes.
End of your business. You are not allowed to be a selfish
individual and say no to relatives. The result: Everyone has
nothing.
The more I worked there and visited government officials doing
absolutely nothing, the more I realized that no one in Senegal had
the idea that a job means work. A job is something given to
you by a relative. It provides the place where you steal
everything to give back to your family.
I couldn't wait to get home. So why would I want to bring
Africa here? Non-Westerners do not magically become American
by arriving on our shores with a visa.
For the rest of my life, I enjoyed the greatest gift of the Peace
Corps: I love and treasure America more than ever. I take
seriously my responsibility to defend our culture and our country
and pass on the American heritage to the next generation.
African problems are made worse by our aid efforts. Senegal
is full of smart, capable people. They will eventually solve
their own country's problems. They will do it on their
terms, not ours. The solution is not to bring Africans here.
We are lectured by Democrats that we must privilege third-world
immigration by the hundred million with chain migration.
They tell us we must end America as a white, Western,
Judeo-Christian, capitalist nation – to prove we are not
racist. I don't need to prove a thing. Leftists want
open borders because they resent whites, resent Western
achievements, and hate America. They want to destroy America
as we know it.
As President Trump asked, why would we do that?
We have the right to choose what kind of country to live in.
I was happy to donate a year of my life as a young woman to help
the poor Senegalese. I am not willing to donate my country.
Dated 2012, but these products are
pre-piss corpcash that should be girlcotted :
https://www.ashtarcommandcrew.net/forum/topics/comprehensive-list-of-companies-that-use-aborted-fetal-cells-as
http://www.cogforlife.org/fetalproductsall.pdf
https://cogforlife.org/wp-content/uploads/fetalproductsall.pdf
Pepsi Beverages on the Boycott
Giving new definition to "hottie" -- Stupit sadomasochist
Muslim idiots punk-rule over craven / suicidal EuroUnion dupes
--
https://voiceofeurope.com/2019/01/african-child-abuse-tradition-of-breast-ironing-on-the-rise-in-uk/
African child abuse tradition of
breast-ironing on the rise in UK
https://www.youtube.com/watch?time_continue=60&v=j4GpGHgOHAk
Acreage Cannabis Ad Rejected For Super Bowl
By CBS
https://list25.com/25-strongest-materials-known-to-man/
https://www.youtube.com/watch?v=0i4tNUx1a1M
25 STRONGEST Materials Known to Man
https://www.youtube.com/watch?v=DjCIye1UvP8
Tardigrade EATS a Cell in Cell Division
Under the Microscope
You tell 'em, Mike !
https://www.naturalnews.com/2019-01-27-to-save-america-trump-must-declare-a-new-american-revolution.html
Sunday, January 27, 2019
ANALYSIS: To save America, Trump must
declare a “New American Revolution”
by: Mike Adams
It is becoming increasingly obvious to nearly everyone that the
anti-Trump deep state is utterly out of control. A rogue, lawless
cabal of treasonous criminals is now horrifyingly close to
overthrowing democracy and achieving the permanent installation of
a corrupt authoritarian regime that will rule over America like
the KGB...
https://www.brighteon.com/5994020421001
You tell 'em, Mark !
https://www.youtube.com/watch?v=xVvVEhdf7vw&feature=youtu.be
What On Earth Is Happening - Episode #197
Mark Passio
"Government is Slavery."